Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-020-15960-z
Title: LipidCreator workbench to probe the lipidomic landscape
Authors: Peng, B.
Kopczynski, D.
Pratt, B.S.
Ejsing, C.S.
Burla, B. 
Hermansson, M.
Benke, P.I. 
Tan, S.H. 
Chan, M.Y. 
Torta, F. 
Schwudke, D.
Meckelmann, S.W.
Coman, C.
Schmitz, O.J.
MacLean, B.
Manke, M.-C.
Borst, O.
Wenk, M.R. 
Hoffmann, N.
Ahrends, R.
Issue Date: 28-Apr-2020
Publisher: Nature Research
Citation: Peng, B., Kopczynski, D., Pratt, B.S., Ejsing, C.S., Burla, B., Hermansson, M., Benke, P.I., Tan, S.H., Chan, M.Y., Torta, F., Schwudke, D., Meckelmann, S.W., Coman, C., Schmitz, O.J., MacLean, B., Manke, M.-C., Borst, O., Wenk, M.R., Hoffmann, N., Ahrends, R. (2020-04-28). LipidCreator workbench to probe the lipidomic landscape. Nature Communications 11 (1) : 2057. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-15960-z
Rights: Attribution 4.0 International
Abstract: Mass spectrometry (MS)-based targeted lipidomics enables the robust quantification of selected lipids under various biological conditions but comprehensive software tools to support such analyses are lacking. Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope labeling, optimize collision energy and generate in silico spectral libraries. We validate LipidCreator assays computationally and analytically and prove that it is capable to generate large targeted experiments to analyze blood and to dissect lipid-signaling pathways such as in human platelets. © 2020, The Author(s).
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/198731
ISSN: 20411723
DOI: 10.1038/s41467-020-15960-z
Rights: Attribution 4.0 International
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