Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41467-020-19080-6
Title: | Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19 | Authors: | Carissimo, G. Xu, W. Kwok, I. Abdad, M.Y. Chan, Y.-H. Fong, S.-W. Puan, K.J. Lee, C.Y.-P. Yeo, N.K.-W. Amrun, S.N. Chee, R.S.-L. How, W. Chan, S. Fan, B.E. Andiappan, A.K. Lee, B. Rötzschke, O. Young, B.E. Leo, Y.-S. Lye, D.C. Renia, L. Ng, L.G. Larbi, A. Ng, L.F. |
Issue Date: | 16-Oct-2020 | Publisher: | Nature Research | Citation: | Carissimo, G., Xu, W., Kwok, I., Abdad, M.Y., Chan, Y.-H., Fong, S.-W., Puan, K.J., Lee, C.Y.-P., Yeo, N.K.-W., Amrun, S.N., Chee, R.S.-L., How, W., Chan, S., Fan, B.E., Andiappan, A.K., Lee, B., Rötzschke, O., Young, B.E., Leo, Y.-S., Lye, D.C., Renia, L., Ng, L.G., Larbi, A., Ng, L.F. (2020-10-16). Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19. Nature Communications 11 (1) : 5243. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-19080-6 | Rights: | Attribution 4.0 International | Abstract: | SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected patients but the cellular mechanisms underlying this progression are still unknown. Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients reveals a dramatic increase in the number of immature neutrophils. This increase strongly correlates with disease severity and is associated with elevated IL-6 and IP-10 levels, two key players in the cytokine storm. The most pronounced decrease in cell counts is observed for CD8 T-cells and VD2 γδ T-cells, which both exhibit increased differentiation and activation. ROC analysis reveals that the count ratio of immature neutrophils to VD2 (or CD8) T-cells predicts pneumonia onset (0.9071) as well as hypoxia onset (0.8908) with high sensitivity and specificity. It would thus be a useful prognostic marker for preventive patient management and improved healthcare resource management. © 2020, The Author(s). | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/198713 | ISSN: | 20411723 | DOI: | 10.1038/s41467-020-19080-6 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1038_s41467_020_19080_6.pdf | 1.81 MB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License