Please use this identifier to cite or link to this item:
https://doi.org/10.1111/jcmm.15384
Title: | Targeting mitochondrial fusion and fission proteins for cardioprotection | Authors: | Hernandez-Resendiz, S. Prunier, F. Girao, H. Dorn, G. Hausenloy, D.J. |
Keywords: | acute myocardial ischaemia/reperfusion injury cardioprotection mitochondrial morphology mitochondrial unfolded protein response mitophagy cardioprotection |
Issue Date: | 2020 | Publisher: | Blackwell Publishing Inc. | Citation: | Hernandez-Resendiz, S., Prunier, F., Girao, H., Dorn, G., Hausenloy, D.J. (2020). Targeting mitochondrial fusion and fission proteins for cardioprotection. Journal of Cellular and Molecular Medicine 24 (12) : 6571-6585. ScholarBank@NUS Repository. https://doi.org/10.1111/jcmm.15384 | Rights: | Attribution 4.0 International | Abstract: | New treatments are needed to protect the myocardium against the detrimental effects of acute ischaemia/reperfusion (IR) injury following an acute myocardial infarction (AMI), in order to limit myocardial infarct (MI) size, preserve cardiac function and prevent the onset of heart failure (HF). Given the critical role of mitochondria in energy production for cardiac contractile function, prevention of mitochondrial dysfunction during acute myocardial IRI may provide novel cardioprotective strategies. In this regard, the mitochondrial fusion and fissions proteins, which regulate changes in mitochondrial morphology, are known to impact on mitochondrial quality control by modulating mitochondrial biogenesis, mitophagy and the mitochondrial unfolded protein response. In this article, we review how targeting these inter-related processes may provide novel treatment targets and new therapeutic strategies for reducing MI size, preventing the onset of HF following AMI. © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd | Source Title: | Journal of Cellular and Molecular Medicine | URI: | https://scholarbank.nus.edu.sg/handle/10635/198065 | ISSN: | 1582-1838 | DOI: | 10.1111/jcmm.15384 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1111_jcmm_15384.pdf | 883.1 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License