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Title: Incidence of Infection of Enterovirus 71 and Coxsackieviruses A6 and A16 among Household Contacts of Index Cases in Dong Thap Province, Southern Vietnam
Authors: Hoang, C.Q.
Nguyen, H.D.
Ho, N.X.
Vu, T.H.T.
Pham, T.T.M.
Nguyen, K.T.
Nguyen, H.T.
Hoang, L.T.
Clapham, H. 
Nguyen, T.T.T.
Phan, L.T.
Issue Date: 2020
Publisher: Hindawi Limited
Citation: Hoang, C.Q., Nguyen, H.D., Ho, N.X., Vu, T.H.T., Pham, T.T.M., Nguyen, K.T., Nguyen, H.T., Hoang, L.T., Clapham, H., Nguyen, T.T.T., Phan, L.T. (2020). Incidence of Infection of Enterovirus 71 and Coxsackieviruses A6 and A16 among Household Contacts of Index Cases in Dong Thap Province, Southern Vietnam. BioMed Research International 2020 : 9850351. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background. Scarce information exists about immunity to hand, foot, and mouth disease (HFMD) among household contacts of index cases in Vietnam and what that means for reducing ongoing HFMD transmission in the community. Methods. We analyzed neutralizing antibodies (NT) and the incidence of enterovirus (EVs) infection among household contacts of index cases in a province where HFMD remains endemic. Throat swab and 2 mL blood samples from household contacts were collected at enrollment, during and after 2 weeks follow-up. Results. The incidence of EV-A71 infection among household contacts was 40/84 (47.6%, 95% Cl: 36.9-58.3%), compared with 106/336 (31.5%, 95% Cl: 26.6-36.5%) for CV-A6 and 36/107 (33.6%, 95% Cl: 24.7-42.6%) for CV-A16. The incidence of CV-A6 infection was fairly constant across ages; in contrast, CV-A71 and CV-A16 had some variation across ages. At baseline, higher geometric mean titer (GMT) of EV-A71, CV-A6, and CV-A16 antibody titers was found for 25-34-year groups (range 216.3 to 305.0) compared to the other age groups. There was a statistically significant difference in GMT values of CV-A6 and CV-A16 between those who had an infection or did not have infection among households with an index case of these serotypes. Conclusions. Our results indicated that adults were becoming infected with HFMD and could be contributing to the transmission. There is, therefore, a need for considering the household setting as an additional target for intervention programs for HFMD. © 2020 C. Q. Hoang et al.
Source Title: BioMed Research International
ISSN: 23146133
DOI: 10.1155/2020/9850351
Rights: Attribution 4.0 International
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