Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11239-020-02118-3
Title: Effect of erroneous body-weight estimation on outcome of thrombolyzed stroke patients
Authors: Paliwal, Prakash R 
Sharma, Arvind K
Komal Kumar, RN
Wong, Lily YH
Chan, Bernard PL
Teoh, Hock Luen 
Sharma, Vijay K 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Hematology
Peripheral Vascular Disease
Cardiovascular System & Cardiology
Acute ischemic stroke
Thrombolysis
Tissue plasminogen activator
Body-weight
TISSUE-PLASMINOGEN ACTIVATOR
ACUTE ISCHEMIC-STROKE
INTRAVENOUS THROMBOLYSIS
INTRACRANIAL HEMORRHAGE
ENDOVASCULAR TREATMENT
T-PA
ALTEPLASE
THROMBECTOMY
TRIAL
APPROXIMATION
Issue Date: 26-Apr-2020
Publisher: SPRINGER
Citation: Paliwal, Prakash R, Sharma, Arvind K, Komal Kumar, RN, Wong, Lily YH, Chan, Bernard PL, Teoh, Hock Luen, Sharma, Vijay K (2020-04-26). Effect of erroneous body-weight estimation on outcome of thrombolyzed stroke patients. JOURNAL OF THROMBOSIS AND THROMBOLYSIS 50 (4) : 921-928. ScholarBank@NUS Repository. https://doi.org/10.1007/s11239-020-02118-3
Abstract: Intravenously administered tissue plasminogen activator (IV-tPA), dose determined by patients’ body-weight, remains the only approved drug treatment for acute ischemic stroke (AIS). Since a shorter onset-to-treatment time results in better functional outcome, treatment is often initiated according to the estimated or last-known body-weight of the patient. This approach may result in underdosing or overdosing of tPA. In this multicenter retrospective study, we evaluated the extent of error in tPA dosing in our AIS cohort and its impact on functional outcome and symptomatic intracranial hemorrhage (SICH). Consecutive AIS patients, receiving IV-tPA, dose determined by the estimated body-weight, at three tertiary centers between January and December 2017 were included. Collected data included information about demographics, cardiovascular risk factors, stroke subtype and National Institute of Health Stroke Scale (NIHSS) score. Estimated and measured body-weights were recorded. Modified Rankin scale (mRS) of 2 or more defined unfavorable outcome. The study included 150 patients. Median age was 64 -years (IQR 55–75) with male preponderance (67%) and median NIHSS score of 9 points (IQR 6–17). Mean measured weight of our study population was 58 (SD 13) kg. Median difference between actual and estimated body-weight was 3 kg (IQR 1.5–6). Difference was more than 10% in 35 (23.3%) patients. Good functional outcome (mRS 0–1) was achieved by 74 (49.3%) patients and 10 (6.8%) developed SICH. NIHSS (OR 1.288; 95% CI 1.157–1.435, p < 0.001) and large artery atherosclerosis (OR 5.878; 95% CI 1.929–17.910, p = 0.002) were independent predictors of unfavorable functional outcome. Our finding of the statistically insignificant 2.5-fold increase in poor outcomes among patients where the estimated and actual weight differed by more than 10% should be interpreted with caution due to the limited sample size. Significant difference occurs between estimated and actual body-weight in a considerable proportion of thrombolysed AIS patients. However, this discrepancy does not affect functional outcome or the risk of SICH.
Source Title: JOURNAL OF THROMBOSIS AND THROMBOLYSIS
URI: https://scholarbank.nus.edu.sg/handle/10635/192400
ISSN: 09295305
1573742X
DOI: 10.1007/s11239-020-02118-3
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