Please use this identifier to cite or link to this item: https://doi.org/10.21203/rs.3.rs-100342/v1
Title: Incidence of Valvular Regurgitation and Leaflet Perforation by Using Automated Titanium Fasteners (CORKNOT®) in Heart Valve Repair or Replacement: Less Usual than Reported
Authors: Sazzad, Faizus Sazzad 
Xian, Ong Zhi
Ler, Ashlynn
Guohao, Chang
Swee, Kang Giap 
Kofidis, Theo
Issue Date: 2021
Publisher: Research Square
Citation: Sazzad, Faizus Sazzad, Xian, Ong Zhi, Ler, Ashlynn, Guohao, Chang, Swee, Kang Giap, Kofidis, Theo (2021). Incidence of Valvular Regurgitation and Leaflet Perforation by Using Automated Titanium Fasteners (CORKNOT®) in Heart Valve Repair or Replacement: Less Usual than Reported. Journal of Cardiothoracic Surgery 16 : 163. ScholarBank@NUS Repository. https://doi.org/10.21203/rs.3.rs-100342/v1
Abstract: Abstract Background: CORKNOT® facilitates a reduction in cardiopulmonary bypass (CPB) time, aortic cross clamp (ACC) time and operative time, but reported to be associated with other complications. We aim to quantify the incidence of valvular complications related to CORKNOT® and determine the feasibility of its use between different valvular surgeries. Methods: Patients who underwent heart valve repair or replacement surgery via the use of automated titanium suture fasteners (CORKNOT®) in a tertiary care hospital were included in the study. This single-centre retrospective study was conducted on 136 patients between January 2016 and June 2018. Results: In our study, the mean operative time was 320.0 ± 97.0 min, mean CPB time was 171.4 ± 76.0 min and the calculated mean ACC time was 105.9 ± 54.0 min. 58 patients (43.9%) underwent minimally invasive valve replacement or repair surgery and 66 patients (50.0%) underwent concomitant procedures. A total of 157 valves were operated on, with 112 (84.8%) single valve surgeries, 15 (11.4%) double valve surgeries and 5 (3.8%) triple valve surgeries. The incidence of moderate and/or severe paravalvular leak (PVL) in immediate post-operative echocardiography was found in 7 (5.3%) patients. There were no reported cases of valvular thrombosis leaflet perforation, device dislodgement or embolization during follow-up echocardiography. Single mitral valve and aortic surgeries had comparable incidences of valvular complications. Conclusion: We conclude the feasibility of CORKNOT® utilisation in mitral and aortic valve surgeries. Additionally, incidence of CORKNOT® related complications in heart valve repair or replacement surgery is less usual in our setting than previously reported. These results motivate the use of CORKNOT® as a valid alternative with complete commitment.
Source Title: Journal of Cardiothoracic Surgery
URI: https://scholarbank.nus.edu.sg/handle/10635/192034
ISSN: 17498090
DOI: 10.21203/rs.3.rs-100342/v1
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