Please use this identifier to cite or link to this item: https://doi.org/10.1002/cnm.3436
Title: Multiscale modeling of a modified Blalock-Taussig surgery in a patient-specific tetralogy of Fallot
Authors: Keramati, Hamed
van Houts, Lex
Chen, Ching Kit 
van de Vosse, Frans
Nakao, Masakazu 
Kim, Sangho 
Leo, Hwa Liang 
Keywords: Science & Technology
Technology
Life Sciences & Biomedicine
Physical Sciences
Engineering, Biomedical
Mathematical & Computational Biology
Mathematics, Interdisciplinary Applications
Engineering
Mathematics
closed-loop
computational fluid dynamics (CFD)
lumped parameter
tetralogy of Fallot
ventricular septal defect
Issue Date: 1-Feb-2021
Publisher: WILEY
Citation: Keramati, Hamed, van Houts, Lex, Chen, Ching Kit, van de Vosse, Frans, Nakao, Masakazu, Kim, Sangho, Leo, Hwa Liang (2021-02-01). Multiscale modeling of a modified Blalock-Taussig surgery in a patient-specific tetralogy of Fallot. INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING 37 (4). ScholarBank@NUS Repository. https://doi.org/10.1002/cnm.3436
Abstract: Tetralogy of Fallot (TOF) is a congenital heart anomaly that causes a drastic reduction in the oxygen level. In this study, we coupled a lumped-parameter model with a patient-specific three-dimensional (3D) model which included a modified Blalock-Taussig (MBT) shunt. By forming a closed loop, we investigated the effects of certain parameters on the flow rates and the pressures at different locations of the developed network. A local sensitivity analysis on an initial zero-dimensional (0D) closed-loop model was conducted. The 0D lumped parameter (LP) model was then refined based on the results of the multiscale 0D-3D model and the local sensitivity analysis was repeated for the refined 0D model. It was shown that the maximum pressure of the pulmonary bed had the highest sensitivity of 94% to the diameter of MBT shunt. We observed that the existence of the flow in the shunt during the diastole caused an elevated wall shear stress (WSS) in the pulmonary artery. In this work, we calculated the flow velocity and pressure field in a 3D patient-specific aorta with an MBT shunt, and then we used the results to increase the accuracy of our LP model to simulate numerous 0D simulations in a significantly shorter time, which is potentially applicable for medical decision-making.
Source Title: INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
URI: https://scholarbank.nus.edu.sg/handle/10635/191494
ISSN: 20407939
20407947
DOI: 10.1002/cnm.3436
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