Please use this identifier to cite or link to this item: https://doi.org/10.1021/acs.chemmater.0c02700
Title: Modulating Cell Specificity and Subcellular Localization by Molecular Charges and Lipophilicity
Authors: Feng, Guangxue 
Wang, Can 
Chen, Chengjian 
Pan, Yutong 
Wu, Min
Wang, Yuanbo 
Liu, Jie 
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Physical
Materials Science, Multidisciplinary
Chemistry
Materials Science
AGGREGATION-INDUCED EMISSION
SINGLET OXYGEN
SELECTIVE CYTOTOXICITY
PHOTODYNAMIC THERAPY
CANCER-CELLS
ANTICANCER
MITOCHONDRIA
PHOTOSENSITIZERS
PERMEABILITY
CHALLENGES
Issue Date: 2020
Publisher: AMER CHEMICAL SOC
Citation: Feng, Guangxue, Wang, Can, Chen, Chengjian, Pan, Yutong, Wu, Min, Wang, Yuanbo, Liu, Jie, Liu, Bin (2020). Modulating Cell Specificity and Subcellular Localization by Molecular Charges and Lipophilicity. CHEMISTRY OF MATERIALS 32 (24) : 10383-10393. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.chemmater.0c02700
Abstract: The precise treatment of cancer requires maximized lesion to cancer cells and minimized damage to normal cells; however, the current theranostic nanomaterials have limited generic theranostic specificity to cancer cells. Herein, as a proof of concept, a small-molecular system simultaneously possessing on-site fluorescence light-up feature, universal cancer cell selectivity, controllable subcellular localization, and activated therapeutic function is developed for cancer theranostics. These molecular probes are composed of photosensitizers (PSs) with the aggregation-induced emission (AIE) feature as the core and aliphatic chains containing lipophilic cations as the arms, which show fluorescence light-up upon entering cancer cells. The charges and lipophilicity of these light-up probes are fine-tuned by the number of lipophilic cations, which modulate their cancer cell selectivity and subcellular localization, where the synthesized AIE PS with four positive charges (TPETM-4+) shows the highest differentiation toward all tested cancer cells over normal ones; neutrally charged TPETM-2 with two arms stains the cytoplasm, TPETM-2+ with two positive charges stains the mitochondria, while TPETM-4+ labels the lysosome. Moreover, under light irradiation, TPETM-4+ exhibits specific photodynamic ablation toward cancer cells over normal ones. This study proposes a new approach to design delivery systems for generic cancer cell selectivity with subcellular localization control, which opens up new opportunities for precise cancer therapy.
Source Title: CHEMISTRY OF MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/188621
ISSN: 08974756
15205002
DOI: 10.1021/acs.chemmater.0c02700
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