Please use this identifier to cite or link to this item: https://doi.org/10.1021/acs.chemmater.0c02700
DC FieldValue
dc.titleModulating Cell Specificity and Subcellular Localization by Molecular Charges and Lipophilicity
dc.contributor.authorFeng, Guangxue
dc.contributor.authorWang, Can
dc.contributor.authorChen, Chengjian
dc.contributor.authorPan, Yutong
dc.contributor.authorWu, Min
dc.contributor.authorWang, Yuanbo
dc.contributor.authorLiu, Jie
dc.contributor.authorLiu, Bin
dc.date.accessioned2021-04-07T03:55:13Z
dc.date.available2021-04-07T03:55:13Z
dc.date.issued2020
dc.identifier.citationFeng, Guangxue, Wang, Can, Chen, Chengjian, Pan, Yutong, Wu, Min, Wang, Yuanbo, Liu, Jie, Liu, Bin (2020). Modulating Cell Specificity and Subcellular Localization by Molecular Charges and Lipophilicity. CHEMISTRY OF MATERIALS 32 (24) : 10383-10393. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.chemmater.0c02700
dc.identifier.issn08974756
dc.identifier.issn15205002
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/188621
dc.description.abstractThe precise treatment of cancer requires maximized lesion to cancer cells and minimized damage to normal cells; however, the current theranostic nanomaterials have limited generic theranostic specificity to cancer cells. Herein, as a proof of concept, a small-molecular system simultaneously possessing on-site fluorescence light-up feature, universal cancer cell selectivity, controllable subcellular localization, and activated therapeutic function is developed for cancer theranostics. These molecular probes are composed of photosensitizers (PSs) with the aggregation-induced emission (AIE) feature as the core and aliphatic chains containing lipophilic cations as the arms, which show fluorescence light-up upon entering cancer cells. The charges and lipophilicity of these light-up probes are fine-tuned by the number of lipophilic cations, which modulate their cancer cell selectivity and subcellular localization, where the synthesized AIE PS with four positive charges (TPETM-4+) shows the highest differentiation toward all tested cancer cells over normal ones; neutrally charged TPETM-2 with two arms stains the cytoplasm, TPETM-2+ with two positive charges stains the mitochondria, while TPETM-4+ labels the lysosome. Moreover, under light irradiation, TPETM-4+ exhibits specific photodynamic ablation toward cancer cells over normal ones. This study proposes a new approach to design delivery systems for generic cancer cell selectivity with subcellular localization control, which opens up new opportunities for precise cancer therapy.
dc.language.isoen
dc.publisherAMER CHEMICAL SOC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectPhysical Sciences
dc.subjectTechnology
dc.subjectChemistry, Physical
dc.subjectMaterials Science, Multidisciplinary
dc.subjectChemistry
dc.subjectMaterials Science
dc.subjectAGGREGATION-INDUCED EMISSION
dc.subjectSINGLET OXYGEN
dc.subjectSELECTIVE CYTOTOXICITY
dc.subjectPHOTODYNAMIC THERAPY
dc.subjectCANCER-CELLS
dc.subjectANTICANCER
dc.subjectMITOCHONDRIA
dc.subjectPHOTOSENSITIZERS
dc.subjectPERMEABILITY
dc.subjectCHALLENGES
dc.typeArticle
dc.date.updated2021-04-07T00:59:09Z
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1021/acs.chemmater.0c02700
dc.description.sourcetitleCHEMISTRY OF MATERIALS
dc.description.volume32
dc.description.issue24
dc.description.page10383-10393
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Modulating Cell Specificity and Subcellular Localization by Molecular Charges and Lipophilicity.pdfSubmitted version2.87 MBAdobe PDF

OPEN

Pre-printView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.