Please use this identifier to cite or link to this item:
https://doi.org/10.1021/acs.chemmater.0c02700
DC Field | Value | |
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dc.title | Modulating Cell Specificity and Subcellular Localization by Molecular Charges and Lipophilicity | |
dc.contributor.author | Feng, Guangxue | |
dc.contributor.author | Wang, Can | |
dc.contributor.author | Chen, Chengjian | |
dc.contributor.author | Pan, Yutong | |
dc.contributor.author | Wu, Min | |
dc.contributor.author | Wang, Yuanbo | |
dc.contributor.author | Liu, Jie | |
dc.contributor.author | Liu, Bin | |
dc.date.accessioned | 2021-04-07T03:55:13Z | |
dc.date.available | 2021-04-07T03:55:13Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Feng, Guangxue, Wang, Can, Chen, Chengjian, Pan, Yutong, Wu, Min, Wang, Yuanbo, Liu, Jie, Liu, Bin (2020). Modulating Cell Specificity and Subcellular Localization by Molecular Charges and Lipophilicity. CHEMISTRY OF MATERIALS 32 (24) : 10383-10393. ScholarBank@NUS Repository. https://doi.org/10.1021/acs.chemmater.0c02700 | |
dc.identifier.issn | 08974756 | |
dc.identifier.issn | 15205002 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/188621 | |
dc.description.abstract | The precise treatment of cancer requires maximized lesion to cancer cells and minimized damage to normal cells; however, the current theranostic nanomaterials have limited generic theranostic specificity to cancer cells. Herein, as a proof of concept, a small-molecular system simultaneously possessing on-site fluorescence light-up feature, universal cancer cell selectivity, controllable subcellular localization, and activated therapeutic function is developed for cancer theranostics. These molecular probes are composed of photosensitizers (PSs) with the aggregation-induced emission (AIE) feature as the core and aliphatic chains containing lipophilic cations as the arms, which show fluorescence light-up upon entering cancer cells. The charges and lipophilicity of these light-up probes are fine-tuned by the number of lipophilic cations, which modulate their cancer cell selectivity and subcellular localization, where the synthesized AIE PS with four positive charges (TPETM-4+) shows the highest differentiation toward all tested cancer cells over normal ones; neutrally charged TPETM-2 with two arms stains the cytoplasm, TPETM-2+ with two positive charges stains the mitochondria, while TPETM-4+ labels the lysosome. Moreover, under light irradiation, TPETM-4+ exhibits specific photodynamic ablation toward cancer cells over normal ones. This study proposes a new approach to design delivery systems for generic cancer cell selectivity with subcellular localization control, which opens up new opportunities for precise cancer therapy. | |
dc.language.iso | en | |
dc.publisher | AMER CHEMICAL SOC | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Physical Sciences | |
dc.subject | Technology | |
dc.subject | Chemistry, Physical | |
dc.subject | Materials Science, Multidisciplinary | |
dc.subject | Chemistry | |
dc.subject | Materials Science | |
dc.subject | AGGREGATION-INDUCED EMISSION | |
dc.subject | SINGLET OXYGEN | |
dc.subject | SELECTIVE CYTOTOXICITY | |
dc.subject | PHOTODYNAMIC THERAPY | |
dc.subject | CANCER-CELLS | |
dc.subject | ANTICANCER | |
dc.subject | MITOCHONDRIA | |
dc.subject | PHOTOSENSITIZERS | |
dc.subject | PERMEABILITY | |
dc.subject | CHALLENGES | |
dc.type | Article | |
dc.date.updated | 2021-04-07T00:59:09Z | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.doi | 10.1021/acs.chemmater.0c02700 | |
dc.description.sourcetitle | CHEMISTRY OF MATERIALS | |
dc.description.volume | 32 | |
dc.description.issue | 24 | |
dc.description.page | 10383-10393 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Modulating Cell Specificity and Subcellular Localization by Molecular Charges and Lipophilicity.pdf | Submitted version | 2.87 MB | Adobe PDF | OPEN | Pre-print | View/Download |
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