Please use this identifier to cite or link to this item: https://doi.org/10.1097/WNR.0b013e3283407204
Title: Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia
Authors: Lai, Mitchell KP 
Chen, Christopher P 
Hope, Tony
Esiri, Margaret M
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
aggression
Alzheimer's disease
dementia
hippocampus
neurofibrillary tangles
neuropsychiatric behaviours
ALZHEIMERS-DISEASE
NEUROPSYCHIATRIC SYMPTOMS
PSYCHIATRIC-SYMPTOMS
Issue Date: 8-Dec-2010
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: Lai, Mitchell KP, Chen, Christopher P, Hope, Tony, Esiri, Margaret M (2010-12-08). Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia. NEUROREPORT 21 (17) : 1111-1115. ScholarBank@NUS Repository. https://doi.org/10.1097/WNR.0b013e3283407204
Abstract: Neuropsychiatric behaviours occur frequently in Alzheimer's disease and other dementias and are thought to arise from the neurodegenerative process. However, it is unclear whether neurodegenerative changes in the hippocampus are associated with neuropsychiatric behaviours such as aggression. In this study, semiquantitative measurements of cell loss, atrophy, neuritic plaque and neurofibrillary tangle load in the postmortem hippocampus were taken for dementia patients, prospectively assessed for neuropsychiatric behaviours. It was found that increased tangle load, but not other hippocampal neuropathological variables, was associated with increased severity of aggressive behaviours and presence of chronic aggression. This study suggests a pathogenic link between neurofibrillary tangle load and aggressive behaviours in the hippocampus of dementia patients. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Source Title: NEUROREPORT
URI: https://scholarbank.nus.edu.sg/handle/10635/188402
ISSN: 09594965
1473558X
DOI: 10.1097/WNR.0b013e3283407204
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