Please use this identifier to cite or link to this item: https://doi.org/10.3233/JAD-2010-1398
Title: Altered NCAM Expression Associated with the Cholinergic System in Alzheimer's Disease
Authors: Aisa, Barbara
Gil-Bea, Francisco J
Solas, Maite
Garcia-Alloza, Monica
Chen, Christopher P 
Lai, Mitchell K 
Francis, Paul T
Javier Ramirez, Maria
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
BDNF
ChAT
cognitive deficits
frontal cortex (BA10)
MMSE
plasticity
temporal cortex (BA20)
CELL-ADHESION MOLECULE
NEUROTROPHIC-FACTOR
HIPPOCAMPAL PLASTICITY
SYNAPTIC PLASTICITY
APOLIPOPROTEIN-E
MESSENGER-RNA
UP-REGULATION
HUMAN BRAIN
LONG-TERM
DEFICITS
Issue Date: 1-Jan-2010
Publisher: IOS PRESS
Citation: Aisa, Barbara, Gil-Bea, Francisco J, Solas, Maite, Garcia-Alloza, Monica, Chen, Christopher P, Lai, Mitchell K, Francis, Paul T, Javier Ramirez, Maria (2010-01-01). Altered NCAM Expression Associated with the Cholinergic System in Alzheimer's Disease. JOURNAL OF ALZHEIMERS DISEASE 20 (2) : 659-668. ScholarBank@NUS Repository. https://doi.org/10.3233/JAD-2010-1398
Abstract: Neurotransmitter system dysfunction and synapse loss have been recognized as hallmarks of Alzheimer's disease (AD). Our hypothesis is that specific neurochemical populations of neurons might be more vulnerable to degeneration in AD due to particular deficits in synaptic plasticity. We have studied, in postmortem brain tissue, the relationship between levels of synaptic markers (NCAM and BDNF), neurochemical measurements (cholinacetyltransferase activity, serotonin, dopamine, GABA, and glutamate levels), and clinical data (cognitive status measured as MMSE score). NCAM levels in frontal and temporal cortex from AD patients were significantly lower than control patients. Interestingly, these reductions in NCAM levels were associated to an ApoE4 genotype. Levels of BDNF were also significantly reduced in both frontal and temporal regions in AD patients. The ratio between plasticity markers and neurochemical measurements was used to study which of the neurochemical populations was particularly associated to plasticity changes. In both the frontal and temporal cortex, there was a significant reduction in the ChAT/NCAM ratio in AD samples compared to controls. None of the ratios to BDNF were different between control and AD samples. Furthermore, Pearson's product moment showed a significant positive correlation between MMSE score and the ChAT/NCAM ratio in frontal cortex (n=19; r=0.526*; p=0.037) as well as in temporal cortex (n=19; r=0.601*; p=0.018) in AD patients. Altogether, these data suggest a potential involvement of NCAM expressing neurons in the cognitive deficits in AD. © 2010 - IOS Press and the authors. All rights reserved.
Source Title: JOURNAL OF ALZHEIMERS DISEASE
URI: https://scholarbank.nus.edu.sg/handle/10635/188383
ISSN: 13872877
18758908
DOI: 10.3233/JAD-2010-1398
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