Please use this identifier to cite or link to this item:
Title: cGAS-STING pathway in oncogenesis and cancer therapeutics
Authors: Hoong, BYD
Gan, YH 
Liu, H 
Chen, ES 
Keywords: STING
cyclic GMP-AMP synthase
stimulator of interferon
Issue Date: 28-Jul-2020
Publisher: Impact Journals, LLC
Citation: Hoong, BYD, Gan, YH, Liu, H, Chen, ES (2020-07-28). cGAS-STING pathway in oncogenesis and cancer therapeutics. Oncotarget 11 (30) : 2930-2955. ScholarBank@NUS Repository.
Abstract: © Hoong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The host innate immunity offers the first line of defense against infection. However, recent evidence shows that the host innate immunity is also critical in sensing the presence of cytoplasmic DNA derived from genomic instability events, such as DNA damage and defective cell cycle progression. This is achieved through the cyclic GMP-AMP synthase (cGAS)/Stimulator of interferon (IFN) genes (STING) pathway. Here we discuss recent insights into the regulation of this pathway in cancer immunosurveillance, and the downstream signaling cascades that coordinate immune cell recruitment to the tumor microenvironment to destroy transformed cells through cellular senescence or cell death programs. Its central role in immunosurveillance positions the cGAS-STING pathway as an attractive anti-cancer immunotherapeutic drug target for chemical agonists or vaccine adjuvants and suggests a key node to be targeted in a synthetic lethal approach. We also discuss adaptive mechanisms used by cancer cells to circumvent cGAS-STING signaling and present evidence linking chronic cGAS-STING activation to inflammation-induced carcinogenesis, cautioning against the use of activating the cGAS-STING pathway as an anti-tumor immunotherapy. A deeper mechanistic understanding of the cGAS-STING pathway will aid in the identification of potentially efficacious anti-cancer therapeutic targets.
Source Title: Oncotarget
ISSN: 19492553
DOI: 10.18632/oncotarget.27673
Appears in Collections:Staff Publications
Students Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
cGAS-STING pathway in oncogenesis and cancer therapeutics.pdfPublished version1.7 MBAdobe PDF



Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.