Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/184187
Title: A morpho-molecular prognostic model for hepatocellular carcinoma
Authors: Srivastava, S 
Wong, KF 
Ong, CW 
Chan, YH 
Yeoh, KG 
Teh, M 
Luk, JM 
Salto-Tellez, M 
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
p53
microvessel density
prognosis
liver cancer
survival
PROTEIN EXPRESSION
SURVIVAL
CANCER
CLASSIFICATION
ANGIOGENESIS
BIOMARKERS
MARKER
Issue Date: 10-Jul-2012
Publisher: NATURE PUBLISHING GROUP
Citation: Srivastava, S, Wong, KF, Ong, CW, Chan, YH, Yeoh, KG, Teh, M, Luk, JM, Salto-Tellez, M (2012-07-10). A morpho-molecular prognostic model for hepatocellular carcinoma. BRITISH JOURNAL OF CANCER 107 (2) : 334-339. ScholarBank@NUS Repository.
Abstract: Background: Hepatocellular carcinoma (HCC) is the third common cause of cancer-related deaths and its prognostication is still suboptimal. The aim of this study was to establish a new prognostication algorithm for HCC. Methods: In all, 13 biomarkers related to the etiopathogenesis of HCC were evaluated by immunohistochemistry using tissue microarrays containing 121 primary HCC resection cases, and validated in subsequent cohort of 85 HCC cases. The results were compared with Affymetrix Gene Chip Human Genome U133Plus microarray data in a separate cohort of 228 HCC patients. Results: On immunohistochemical evaluation and multivariate Cox regression analysis p53, alpha fetaprotein (AFP), CD44 and CD31, tumour size and vascular invasion, were significant predictors for worse survival in HCC patients. A morpho-molecular prognostic model (MMPM) was constructed and it was a significant independent predictor for overall survival (OS) and relapse-free survival (RFS) (P<0.000). The OS and RFS of HCClow was higher (104 and 78 months) as compared with HCChigh (73 and 43 months) (P<0.0001for OS and RFS). Hepatocellular carcinoma patients with higher stage (III+IV), >5 cm tumour size, positive vascular invasion and satellitosis belonged to HCChigh group. The validation group reproduced the same findings. Gene expression analysis confirmed that 7 of the 12 biomarkers were overexpressed in >50% of tumour samples and significant overexpression in tumour samples was observed in AFP, CD31, CD117 and Ki-67 genes. Conclusion: The MMPM, based on the expression of selected proteins and clinicopathological parameters, can be used to classify HCC patients between good vs poor prognosis and high vs low risk of recurrence following hepatic resection. © 2012 Cancer Research UK All rights reserved.
Source Title: BRITISH JOURNAL OF CANCER
URI: https://scholarbank.nus.edu.sg/handle/10635/184187
ISSN: 00070920
15321827
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
A morpho-molecular prognostic model for hepatocellular carcinoma.pdf487.86 kBAdobe PDF

OPEN

PublishedView/Download

Page view(s)

48
checked on Apr 15, 2021

Download(s)

1
checked on Apr 15, 2021

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.