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https://doi.org/10.1007/s00428-015-1745-4
Title: | Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma | Authors: | Srivastava, Supriya Thakkar, Bhavin Yeoh, Khay Guan Ho, Khek Yu Teh, Ming Soong, Richie Salto-Tellez, Manuel |
Keywords: | Science & Technology Life Sciences & Biomedicine Pathology CA-IX HIF-1 alpha Liver cancer Prognosis Survival Wnt pathway CARBONIC-ANHYDRASE-IX HUMAN HEPATOMA-CELLS INDUCIBLE FACTOR-I BETA-CATENIN NATURAL-HISTORY TUMOR HYPOXIA E-CADHERIN MARKER LIVER HIF-1-ALPHA |
Issue Date: | 1-May-2015 | Publisher: | SPRINGER | Citation: | Srivastava, Supriya, Thakkar, Bhavin, Yeoh, Khay Guan, Ho, Khek Yu, Teh, Ming, Soong, Richie, Salto-Tellez, Manuel (2015-05-01). Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma. VIRCHOWS ARCHIV 466 (5) : 541-548. ScholarBank@NUS Repository. https://doi.org/10.1007/s00428-015-1745-4 | Abstract: | © 2015, Springer-Verlag Berlin Heidelberg. In the development and progression of hepatocellular carcinoma, tumor hypoxia plays an important role, as does activation of the Wnt pathway. The aim of this study was to characterize the expression and interrelationship between hypoxia and Wnt-pathway-associated proteins as prognostic factors for hepatocellular carcinoma. Expression of HIF-1α, CA-IX, E-cadherin, β-catenin, and Ki-67 was assessed by immunohistochemistry in 179 primary hepatocellular carcinoma cases. Univariate and multivariate analyses were performed to assess the relationship between the clinicopathological factors, protein expression, overall survival (OS), and recurrence-free survival (RFS). By univariate analysis, tumor stage, size, satellitosis, and vascular invasion were confirmed as prognostic factors for worse OS and RFS. High expression of HIF-1α, CA-IX, β-catenin, Ki-67, and E-cadherin was observed in 60, 15, 64, 8, and 64 % of tumors, respectively, and this was significantly associated with poor OS. CA-IX, HIF-1α, and E-cadherin were independent predictors of poor prognosis. We stratified 169 patients into four groups according to the expression level of hypoxia and Wnt pathway markers. The group with high expression of both hypoxia and Wnt-pathway-associated proteins showed worst OS. The poor survival of this group was also significant in patients with early stage disease and tumor size of less than 5 cm (p < 0.05). We identified a subgroup of hepatocellular carcinoma patients with high expression of both hypoxia and Wnt pathway proteins and found this predictive of poor survival. The therapeutic options for this group might need to be revisited. | Source Title: | VIRCHOWS ARCHIV | URI: | https://scholarbank.nus.edu.sg/handle/10635/184185 | ISSN: | 09456317 14322307 |
DOI: | 10.1007/s00428-015-1745-4 |
Appears in Collections: | Staff Publications Elements |
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