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Title: Response and progression-free survival in oropharynx squamous cell carcinoma assessed by pretreatment perfusion CT: Comparison with tumor volume measurements
Authors: Bisdas, S
Rumboldt, Z
Wagenblast, J
Baghi, M
Koh, T.S 
Hambek, M
Vogl, T.J
Mack, M.G
Keywords: cisplatin
iodinated contrast medium
blood flow
blood volume
cancer chemotherapy
cancer combination chemotherapy
cancer radiotherapy
cancer surgery
clinical article
comparative study
computer assisted tomography
continuous infusion
controlled study
multiple cycle treatment
oropharynx carcinoma
perfusion computed tomography
progression free survival
sensitivity and specificity
squamous cell carcinoma
tumor volume
Antineoplastic Combined Chemotherapy Protocols
Blood Flow Velocity
Blood Volume
Carcinoma, Squamous Cell
Contrast Media
Disease Progression
Follow-Up Studies
Kaplan-Meiers Estimate
Middle Aged
Neoplasm Recurrence, Local
Oropharyngeal Neoplasms
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
ROC Curve
Sensitivity and Specificity
Survival Rate
Tomography, X-Ray Computed
Issue Date: 2009
Publisher: American Society of Neuroradiology
Citation: Bisdas, S, Rumboldt, Z, Wagenblast, J, Baghi, M, Koh, T.S, Hambek, M, Vogl, T.J, Mack, M.G (2009). Response and progression-free survival in oropharynx squamous cell carcinoma assessed by pretreatment perfusion CT: Comparison with tumor volume measurements. American Journal of Neuroradiology 30 (4) : 793-799. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background and Purpose: Perfusion CT (PCT) provides a rapid, reliable, and non-invasive technique for assessing tumor vascularity. The purpose of this study was to assess whether pretreatment dynamic perfusion CT (PCT) may predict response to induction chemotherapy and midterm progression-free survival (PFS) in advanced oropharynx squamous cell carcinoma (SCCA) and to compare the results with those derived by tumor volume measurements. MATERIALS AND METHODS: Nineteen patients underwent routine contrast-enhanced CT (CECT), pretreatment PCT, and conventional endoscopy. Tumor response was determined according to radiologic (RECIST) criteria. The PCT parameters, tumor volume, radiologic response, and PFS were analyzed with use of Cox-proportional hazards model, receiver operating characteristic (ROC), and Kaplan-Meier analysis. Results: The baseline blood flow (BF), blood volume (BV), and permeability surface area product (PS) were significantly higher, whereas mean transit time (MTT) was significantly lower in the responders than in the nonresponders (P < .002). BV showed 100% sensitivity, MTT and PS had the highest specificity (100%), and BF showed 84.2% sensitivity and 66.7% specificity for prediction of tumor response after induction chemotherapy. The pretreatment tumor volume correlated with PFS in the pooled patients group (r = 0.4; P < .0001), whereas postinduction tumor volume correlated significantly with PFS in the responders and nonresponders (r = 0.22-0.64; P < .006). Pretreatment tumor volume (P = .0001) and BF (P = .001) were significant predictors for PFS. Conclusions: Pretreatment PCT parameters may predict response after induction chemotherapy. Tumor volume and BF values may predict PFS in patients with advanced oropharyngeal SCCA.
Source Title: American Journal of Neuroradiology
ISSN: 0195-6108
DOI: 10.3174/ajnr.A1449
Rights: Attribution 4.0 International
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