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https://doi.org/10.1186/bcr1737
Title: | Is breast cancer prognosis inherited? | Authors: | Hartman, M Lindström, L Dickman, P.W Adami, H.-O Hall, P Czene, K |
Keywords: | adult aged article breast cancer cancer mortality cancer registry cancer risk cancer survival cause of death cohort analysis controlled study daughter female follow up genetic trait human inheritance major clinical study mother outcome assessment prognosis survival rate Sweden breast tumor genetics middle aged mortality nuclear family pathophysiology register survival survivor Sweden time Adult Aged Breast Neoplasms Cause of Death Cohort Studies Female Follow-Up Studies Humans Middle Aged Nuclear Family Prognosis Registries Survival Analysis Survivors Sweden Time Factors |
Issue Date: | 2007 | Citation: | Hartman, M, Lindström, L, Dickman, P.W, Adami, H.-O, Hall, P, Czene, K (2007). Is breast cancer prognosis inherited?. Breast Cancer Research 9 (3) : R39. ScholarBank@NUS Repository. https://doi.org/10.1186/bcr1737 | Rights: | Attribution 4.0 International | Abstract: | Introduction: A genetic component is well established in the etiology of breast cancer. It is not well known, however, whether genetic traits also influence prognostic features of the malignant phenotype. Methods: We carried out a population-based cohort study in Sweden based on the nationwide Multi-Generation Register. Among all women with breast cancer diagnosed from 1961 to 2001, 2,787 mother-daughter pairs and 831 sister pairs with breast cancer were identified; we achieved complete follow-up and classified 5-year breast cancer-specific prognosis among proband (mother or oldest sister) into tertiles as poor, intermediary, or good. We used Kaplan-Meier estimates of survival proportions and Cox models to calculate relative risks of dying from breast cancer within 5 years depending on the proband's outcome. Results: The 5-year survivalproportion among daughters whose mothers died within 5 years was 87% compared to 91% if the mother was alive (p = 0.03). Among sisters, the corresponding proportions were 70% and 88%, respectively (p = 0.001). After adjustment for potential confounders, daughters and sisters of a proband with poor prognosis had a 60% higher 5-year breast cancer mortality compared to those of a proband with good prognosis (hazard ratio [HR], 1.6; 95% confidence interval [CI], 1.2 to 2.2; p for trend 0.002). This association was slightly stronger among sisters (HR, 1.8; 95% CI, 1.0 to 3.4) than among daughters (HR, 1.6; 95% CI, 1.1 to 2.3). Conclusion: Breast cancer prognosis of a woman predicts the survival in her first-degree relatives with breast cancer. Our novel findings suggest that breast cancer prognosis might be inherited. © 2007 Hartman et al.; licensee BioMed Central Ltd. | Source Title: | Breast Cancer Research | URI: | https://scholarbank.nus.edu.sg/handle/10635/183284 | ISSN: | 14655411 | DOI: | 10.1186/bcr1737 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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