Please use this identifier to cite or link to this item:
https://doi.org/10.1186/bcr1737
DC Field | Value | |
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dc.title | Is breast cancer prognosis inherited? | |
dc.contributor.author | Hartman, M | |
dc.contributor.author | Lindström, L | |
dc.contributor.author | Dickman, P.W | |
dc.contributor.author | Adami, H.-O | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Czene, K | |
dc.date.accessioned | 2020-11-10T00:45:39Z | |
dc.date.available | 2020-11-10T00:45:39Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Hartman, M, Lindström, L, Dickman, P.W, Adami, H.-O, Hall, P, Czene, K (2007). Is breast cancer prognosis inherited?. Breast Cancer Research 9 (3) : R39. ScholarBank@NUS Repository. https://doi.org/10.1186/bcr1737 | |
dc.identifier.issn | 14655411 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/183284 | |
dc.description.abstract | Introduction: A genetic component is well established in the etiology of breast cancer. It is not well known, however, whether genetic traits also influence prognostic features of the malignant phenotype. Methods: We carried out a population-based cohort study in Sweden based on the nationwide Multi-Generation Register. Among all women with breast cancer diagnosed from 1961 to 2001, 2,787 mother-daughter pairs and 831 sister pairs with breast cancer were identified; we achieved complete follow-up and classified 5-year breast cancer-specific prognosis among proband (mother or oldest sister) into tertiles as poor, intermediary, or good. We used Kaplan-Meier estimates of survival proportions and Cox models to calculate relative risks of dying from breast cancer within 5 years depending on the proband's outcome. Results: The 5-year survivalproportion among daughters whose mothers died within 5 years was 87% compared to 91% if the mother was alive (p = 0.03). Among sisters, the corresponding proportions were 70% and 88%, respectively (p = 0.001). After adjustment for potential confounders, daughters and sisters of a proband with poor prognosis had a 60% higher 5-year breast cancer mortality compared to those of a proband with good prognosis (hazard ratio [HR], 1.6; 95% confidence interval [CI], 1.2 to 2.2; p for trend 0.002). This association was slightly stronger among sisters (HR, 1.8; 95% CI, 1.0 to 3.4) than among daughters (HR, 1.6; 95% CI, 1.1 to 2.3). Conclusion: Breast cancer prognosis of a woman predicts the survival in her first-degree relatives with breast cancer. Our novel findings suggest that breast cancer prognosis might be inherited. © 2007 Hartman et al.; licensee BioMed Central Ltd. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | adult | |
dc.subject | aged | |
dc.subject | article | |
dc.subject | breast cancer | |
dc.subject | cancer mortality | |
dc.subject | cancer registry | |
dc.subject | cancer risk | |
dc.subject | cancer survival | |
dc.subject | cause of death | |
dc.subject | cohort analysis | |
dc.subject | controlled study | |
dc.subject | daughter | |
dc.subject | female | |
dc.subject | follow up | |
dc.subject | genetic trait | |
dc.subject | human | |
dc.subject | inheritance | |
dc.subject | major clinical study | |
dc.subject | mother | |
dc.subject | outcome assessment | |
dc.subject | prognosis | |
dc.subject | survival rate | |
dc.subject | Sweden | |
dc.subject | breast tumor | |
dc.subject | genetics | |
dc.subject | middle aged | |
dc.subject | mortality | |
dc.subject | nuclear family | |
dc.subject | pathophysiology | |
dc.subject | register | |
dc.subject | survival | |
dc.subject | survivor | |
dc.subject | Sweden | |
dc.subject | time | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Breast Neoplasms | |
dc.subject | Cause of Death | |
dc.subject | Cohort Studies | |
dc.subject | Female | |
dc.subject | Follow-Up Studies | |
dc.subject | Humans | |
dc.subject | Middle Aged | |
dc.subject | Nuclear Family | |
dc.subject | Prognosis | |
dc.subject | Registries | |
dc.subject | Survival Analysis | |
dc.subject | Survivors | |
dc.subject | Sweden | |
dc.subject | Time Factors | |
dc.type | Article | |
dc.contributor.department | SURGERY | |
dc.description.doi | 10.1186/bcr1737 | |
dc.description.sourcetitle | Breast Cancer Research | |
dc.description.volume | 9 | |
dc.description.issue | 3 | |
dc.description.page | R39 | |
Appears in Collections: | Staff Publications Elements |
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