Please use this identifier to cite or link to this item: https://doi.org/10.1186/1532-429X-10-6
Title: Assessment of myocardial infarction in mice by Late Gadolinium Enhancement MR imaging using an inversion recovery pulse sequence at 9.4T
Authors: Chapon, C
Herlihy, A.H
Bhakoo, K.K 
Keywords: gadolinium
contrast medium
diagnostic agent
gadolinium pentetate
animal experiment
animal model
animal tissue
article
controlled study
heart infarction
heart muscle
heart rate
image enhancement
male
mouse
nonhuman
nuclear magnetic resonance imaging
priority journal
pulse rate
signal noise ratio
analysis of variance
animal
C57BL mouse
disease model
feasibility study
heart infarction
methodology
Analysis of Variance
Animals
Contrast Media
Disease Models, Animal
Feasibility Studies
Gadolinium DTPA
Heart Rate
Magnetic Resonance Imaging
Male
Mice
Mice, Inbred C57BL
Myocardial Infarction
Issue Date: 2008
Citation: Chapon, C, Herlihy, A.H, Bhakoo, K.K (2008). Assessment of myocardial infarction in mice by Late Gadolinium Enhancement MR imaging using an inversion recovery pulse sequence at 9.4T. Journal of Cardiovascular Magnetic Resonance 10 (1) : 6. ScholarBank@NUS Repository. https://doi.org/10.1186/1532-429X-10-6
Rights: Attribution 4.0 International
Abstract: Purpose: To demonstrate the feasibility of using an inversion recovery pulse sequence and to define the optimal inversion time (TI) to assess myocardial infarction in mice by late gadolinium enhancement (LGE) MRI at 9.4T, and to obtain the maximal contrast between the infarcted and the viable myocardium. Methods: MRI was performed at 9.4T in mice, two days after induction of myocardial infarction (n = 4). For cardiovascular MR imaging, a segmented magnetization-prepared fast low angle shot (MP-FLASH) sequence was used with varied TIs ranging from 40 to 420 ms following administration of gadolinium-DTPA at 0.6 mmol/kg. Contrast-to-noise (CNR) and signal-to-noise ratio (SNR) were measured and compared for each myocardial region of interest (ROI). Results: The optimal TI, which corresponded to a minimum SNR in the normal myocardium, was 268 ms ± 27.3. The SNR in the viable myocardium was significantly different from that found in the infarcted myocardium (17.2 ± 2.4 vs 82.1 ± 10.8; p = 0.006) leading to a maximal relative SI (Signal Intensity) between those two areas (344.9 ± 60.4). Conclusion: Despite the rapid heart rate in mice, our study demonstrates that LGE MRI can be performed at 9.4 T using a protocol similar to the one used for clinical MR diagnosis of myocardial infarction. © 2008 Chapon et al; licensee BioMed Central Ltd..
Source Title: Journal of Cardiovascular Magnetic Resonance
URI: https://scholarbank.nus.edu.sg/handle/10635/183279
ISSN: 10976647
DOI: 10.1186/1532-429X-10-6
Rights: Attribution 4.0 International
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