Please use this identifier to cite or link to this item: https://doi.org/10.1186/bcr2879
Title: Coffee consumption modifies risk of estrogen-receptor negative breast cancer
Authors: Li, J 
Seibold, P
Chang-Claude, J
Flesch-Janys, D
Liu, J
Czene, K
Humphreys, K
Hall, P
Keywords: estrogen receptor
estrogen receptor
adult
aged
article
breast cancer
cancer risk
coffee
controlled study
drinking behavior
female
human
major clinical study
postmenopause
risk reduction
breast tumor
case control study
chemistry
eating
middle aged
postmenopause
risk
Aged
Breast Neoplasms
Case-Control Studies
Coffee
Eating
Female
Humans
Middle Aged
Odds Ratio
Postmenopause
Receptors, Estrogen
Risk
Issue Date: 2011
Citation: Li, J, Seibold, P, Chang-Claude, J, Flesch-Janys, D, Liu, J, Czene, K, Humphreys, K, Hall, P (2011). Coffee consumption modifies risk of estrogen-receptor negative breast cancer. Breast Cancer Research 13 (3) : R49. ScholarBank@NUS Repository. https://doi.org/10.1186/bcr2879
Rights: Attribution 4.0 International
Abstract: Introduction: Breast cancer is a complex disease and may be sub-divided into hormone-responsive (estrogen receptor (ER) positive) and non-hormone-responsive subtypes (ER-negative). Some evidence suggests that heterogeneity exists in the associations between coffee consumption and breast cancer risk, according to different estrogen receptor subtypes. We assessed the association between coffee consumption and postmenopausal breast cancer risk in a large population-based study (2,818 cases and 3,111 controls), overall, and stratified by ER tumour subtypes.Methods: Odds ratios (OR) and corresponding 95% confidence intervals (CI) were estimated using the multivariate logistic regression models fitted to examine breast cancer risk in a stratified case-control analysis. Heterogeneity among ER subtypes was evaluated in a case-only analysis, by fitting binary logistic regression models, treating ER status as a dependent variable, with coffee consumption included as a covariate.Results: In the Swedish study, coffee consumption was associated with a modest decrease in overall breast cancer risk in the age-adjusted model (OR > 5 cups/daycompared to OR ? 1 cup/day: 0.80, 95% CI: 0.64, 0.99, P trend = 0.028). In the stratified case-control analyses, a significant reduction in the risk of ER-negative breast cancer was observed in heavy coffee drinkers (OR > 5 cups/daycompared to OR ? 1 cup/day: 0.43, 95% CI: 0.25, 0.72, P trend = 0.0003) in a multivariate-adjusted model. The breast cancer risk reduction associated with higher coffee consumption was significantly higher for ER-negative compared to ER-positive tumours (P heterogeneity (age-adjusted) = 0.004).Conclusions: A high daily intake of coffee was found to be associated with a statistically significant decrease in ER-negative breast cancer among postmenopausal women. © 2011 Li et al.; licensee BioMed Central Ltd.
Source Title: Breast Cancer Research
URI: https://scholarbank.nus.edu.sg/handle/10635/183257
ISSN: 14655411
DOI: 10.1186/bcr2879
Rights: Attribution 4.0 International
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