Please use this identifier to cite or link to this item: https://doi.org/10.1186/bcr2879
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dc.titleCoffee consumption modifies risk of estrogen-receptor negative breast cancer
dc.contributor.authorLi, J
dc.contributor.authorSeibold, P
dc.contributor.authorChang-Claude, J
dc.contributor.authorFlesch-Janys, D
dc.contributor.authorLiu, J
dc.contributor.authorCzene, K
dc.contributor.authorHumphreys, K
dc.contributor.authorHall, P
dc.date.accessioned2020-11-10T00:40:31Z
dc.date.available2020-11-10T00:40:31Z
dc.date.issued2011
dc.identifier.citationLi, J, Seibold, P, Chang-Claude, J, Flesch-Janys, D, Liu, J, Czene, K, Humphreys, K, Hall, P (2011). Coffee consumption modifies risk of estrogen-receptor negative breast cancer. Breast Cancer Research 13 (3) : R49. ScholarBank@NUS Repository. https://doi.org/10.1186/bcr2879
dc.identifier.issn14655411
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183257
dc.description.abstractIntroduction: Breast cancer is a complex disease and may be sub-divided into hormone-responsive (estrogen receptor (ER) positive) and non-hormone-responsive subtypes (ER-negative). Some evidence suggests that heterogeneity exists in the associations between coffee consumption and breast cancer risk, according to different estrogen receptor subtypes. We assessed the association between coffee consumption and postmenopausal breast cancer risk in a large population-based study (2,818 cases and 3,111 controls), overall, and stratified by ER tumour subtypes.Methods: Odds ratios (OR) and corresponding 95% confidence intervals (CI) were estimated using the multivariate logistic regression models fitted to examine breast cancer risk in a stratified case-control analysis. Heterogeneity among ER subtypes was evaluated in a case-only analysis, by fitting binary logistic regression models, treating ER status as a dependent variable, with coffee consumption included as a covariate.Results: In the Swedish study, coffee consumption was associated with a modest decrease in overall breast cancer risk in the age-adjusted model (OR > 5 cups/daycompared to OR ? 1 cup/day: 0.80, 95% CI: 0.64, 0.99, P trend = 0.028). In the stratified case-control analyses, a significant reduction in the risk of ER-negative breast cancer was observed in heavy coffee drinkers (OR > 5 cups/daycompared to OR ? 1 cup/day: 0.43, 95% CI: 0.25, 0.72, P trend = 0.0003) in a multivariate-adjusted model. The breast cancer risk reduction associated with higher coffee consumption was significantly higher for ER-negative compared to ER-positive tumours (P heterogeneity (age-adjusted) = 0.004).Conclusions: A high daily intake of coffee was found to be associated with a statistically significant decrease in ER-negative breast cancer among postmenopausal women. © 2011 Li et al.; licensee BioMed Central Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectestrogen receptor
dc.subjectestrogen receptor
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbreast cancer
dc.subjectcancer risk
dc.subjectcoffee
dc.subjectcontrolled study
dc.subjectdrinking behavior
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectpostmenopause
dc.subjectrisk reduction
dc.subjectbreast tumor
dc.subjectcase control study
dc.subjectchemistry
dc.subjecteating
dc.subjectmiddle aged
dc.subjectpostmenopause
dc.subjectrisk
dc.subjectAged
dc.subjectBreast Neoplasms
dc.subjectCase-Control Studies
dc.subjectCoffee
dc.subjectEating
dc.subjectFemale
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectOdds Ratio
dc.subjectPostmenopause
dc.subjectReceptors, Estrogen
dc.subjectRisk
dc.typeArticle
dc.contributor.departmentDEPT OF SURGERY
dc.description.doi10.1186/bcr2879
dc.description.sourcetitleBreast Cancer Research
dc.description.volume13
dc.description.issue3
dc.description.pageR49
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