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https://doi.org/10.1186/gb-2012-13-2-r9
| Title: | Predicting the effects of frameshifting indels | Authors: | Hu, J Ng, P.C |
Keywords: | complementary DNA DNA protein accuracy African article Asian classification algorithm classifier CYP3A gene decision tree DNA sequence ethnic group European exon frameshifting indel gene gene cluster gene deletion gene frequency gene function gene insertion genetic conservation HERC2 gene human human genome intron nonhuman protein function sensitivity and specificity sequence alignment SIFT indel algorithm algorithm animal biology Caucasian computer program frameshift mutation genetics indel mutation Negro African Continental Ancestry Group Algorithms Animals Asian Continental Ancestry Group Computational Biology European Continental Ancestry Group Frameshift Mutation Gene Frequency Genome, Human Humans INDEL Mutation Proteins Software |
Issue Date: | 2012 | Citation: | Hu, J, Ng, P.C (2012). Predicting the effects of frameshifting indels. Genome Biology 13 (2) : R9. ScholarBank@NUS Repository. https://doi.org/10.1186/gb-2012-13-2-r9 | Rights: | Attribution 4.0 International | Abstract: | Each human has approximately 50 to 280 frameshifting indels, yet their implications are unknown. We created SIFT Indel, a prediction method for frameshifting indels that has 84% accuracy. The percentage of human frameshifting indels predicted to be gene-damaging is negatively correlated with allele frequency. We also show that although the first frameshifting indel in a gene causes loss of function, there is a tendency for the second frameshifting indel to compensate and restore protein function. SIFT Indel is available at http://sift-dna.org/www/SIFT_indels2.html. © 2012 Hu and Ng; licensee BioMed Central Ltd. | Source Title: | Genome Biology | URI: | https://scholarbank.nus.edu.sg/handle/10635/183237 | ISSN: | 14747596 | DOI: | 10.1186/gb-2012-13-2-r9 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Staff Publications Elements |
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