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Please use this identifier to cite or link to this item: https://doi.org/10.1186/gb-2012-13-2-r9
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dc.titlePredicting the effects of frameshifting indels
dc.contributor.authorHu, J
dc.contributor.authorNg, P.C
dc.date.accessioned2020-11-10T00:37:05Z
dc.date.available2020-11-10T00:37:05Z
dc.date.issued2012
dc.identifier.citationHu, J, Ng, P.C (2012). Predicting the effects of frameshifting indels. Genome Biology 13 (2) : R9. ScholarBank@NUS Repository. https://doi.org/10.1186/gb-2012-13-2-r9
dc.identifier.issn14747596
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183237
dc.description.abstractEach human has approximately 50 to 280 frameshifting indels, yet their implications are unknown. We created SIFT Indel, a prediction method for frameshifting indels that has 84% accuracy. The percentage of human frameshifting indels predicted to be gene-damaging is negatively correlated with allele frequency. We also show that although the first frameshifting indel in a gene causes loss of function, there is a tendency for the second frameshifting indel to compensate and restore protein function. SIFT Indel is available at http://sift-dna.org/www/SIFT_indels2.html. © 2012 Hu and Ng; licensee BioMed Central Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectcomplementary DNA
dc.subjectDNA
dc.subjectprotein
dc.subjectaccuracy
dc.subjectAfrican
dc.subjectarticle
dc.subjectAsian
dc.subjectclassification algorithm
dc.subjectclassifier
dc.subjectCYP3A gene
dc.subjectdecision tree
dc.subjectDNA sequence
dc.subjectethnic group
dc.subjectEuropean
dc.subjectexon
dc.subjectframeshifting indel
dc.subjectgene
dc.subjectgene cluster
dc.subjectgene deletion
dc.subjectgene frequency
dc.subjectgene function
dc.subjectgene insertion
dc.subjectgenetic conservation
dc.subjectHERC2 gene
dc.subjecthuman
dc.subjecthuman genome
dc.subjectintron
dc.subjectnonhuman
dc.subjectprotein function
dc.subjectsensitivity and specificity
dc.subjectsequence alignment
dc.subjectSIFT indel algorithm
dc.subjectalgorithm
dc.subjectanimal
dc.subjectbiology
dc.subjectCaucasian
dc.subjectcomputer program
dc.subjectframeshift mutation
dc.subjectgenetics
dc.subjectindel mutation
dc.subjectNegro
dc.subjectAfrican Continental Ancestry Group
dc.subjectAlgorithms
dc.subjectAnimals
dc.subjectAsian Continental Ancestry Group
dc.subjectComputational Biology
dc.subjectEuropean Continental Ancestry Group
dc.subjectFrameshift Mutation
dc.subjectGene Frequency
dc.subjectGenome, Human
dc.subjectHumans
dc.subjectINDEL Mutation
dc.subjectProteins
dc.subjectSoftware
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.description.doi10.1186/gb-2012-13-2-r9
dc.description.sourcetitleGenome Biology
dc.description.volume13
dc.description.issue2
dc.description.pageR9
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