Please use this identifier to cite or link to this item: https://doi.org/10.20945/2359-3997000000082
Title: The characteristics of blood glucose fluctuations in patients with fulminant type 1 diabetes mellitus in the stable stage
Authors: Wang, J
Liu, B.-L
Li, Z
Li, H.-Q
Sun, R
Hu, Y
Lee, K.-O 
Ye, L 
Su, X.-F
Ma, J.-H
Keywords: antidiabetic agent
C peptide
glucagon
insulin
adult
analysis
blood
blood glucose monitoring
case control study
comparative study
female
glucose blood level
human
insulin dependent diabetes mellitus
male
metabolism
middle aged
nonparametric test
procedures
reference value
retrospective study
Adult
Blood Glucose
Blood Glucose Self-Monitoring
C-Peptide
Case-Control Studies
Diabetes Mellitus, Type 1
Female
Glucagon
Humans
Hypoglycemic Agents
Insulin
Male
Middle Aged
Reference Values
Retrospective Studies
Statistics, Nonparametric
Issue Date: 2018
Citation: Wang, J, Liu, B.-L, Li, Z, Li, H.-Q, Sun, R, Hu, Y, Lee, K.-O, Ye, L, Su, X.-F, Ma, J.-H (2018). The characteristics of blood glucose fluctuations in patients with fulminant type 1 diabetes mellitus in the stable stage. Archives of Endocrinology and Metabolism 62 (6) : 585-590. ScholarBank@NUS Repository. https://doi.org/10.20945/2359-3997000000082
Rights: Attribution 4.0 International
Abstract: Objective: The aim was to characterize blood glucose fluctuations in patients with fulminant type 1 diabetes (FT1DM) at the stable stage using continuous blood glucose monitoring systems (CGMSs). Subjects and methods: Ten patients with FT1DM and 20 patients with classic type 1 diabetes mellitus (T1DM) (the control group) were monitored using CGMSs for 72 hours. Results: The CGMS data showed that the mean blood glucose (MBG), the standard deviation of the blood glucose (SDBG), the mean amplitude glycemic excursions (MAGE), the blood glucose areas and the percentages of blood glucose levels below 13.9 mmol/L were similar between the two groups. However, the percentage of blood glucose levels below 3.9 mmol/L was significantly higher in the FT1DM group compared to the T1DM group (p < 0.05). The minimum (Min) blood glucose level in the FT1DM group was significantly lower than that of the T1DM group (p < 0.05). Patients with FT1DM had severe dysfunction of the islet beta cells and alpha cells compared to patients with T1DM, as indicated by lower C-peptide values and higher glucagon/C-peptide values. Conclusion: In conclusion, patients with FT1DM at the stable stage were more prone to hypoglycemic episodes as recorded by CGMSs, and they had a greater association with severe dysfunction of both the beta and alpha islet cells compared to patients with T1DM. Arch Endocrinol Metab. 2018;62(6):585-90. © 2018, Sociedade Brasileira de Endocrinologia e Metabologia. All rights reserved.
Source Title: Archives of Endocrinology and Metabolism
URI: https://scholarbank.nus.edu.sg/handle/10635/182063
ISSN: 23593997
DOI: 10.20945/2359-3997000000082
Rights: Attribution 4.0 International
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