Please use this identifier to cite or link to this item: https://doi.org/10.1098/rsob.130052
Title: Left-right asymmetry: cilia stir up new surprises in the node.
Authors: Babu, D 
Roy, S. 
Keywords: protein kinase
protein kinase D2
animal
animal embryo
calcium signaling
embryo development
embryology
eukaryotic flagellum
fish
gene expression regulation
human
metabolism
morphogenesis
mouse
movement (physiology)
physiology
signal transduction
Animals
Body Patterning
Calcium Signaling
Cilia
Embryo, Mammalian
Embryo, Nonmammalian
Embryonic Development
Fishes
Gene Expression Regulation, Developmental
Humans
Mice
Movement
Protein Kinases
Signal Transduction
Issue Date: 2013
Citation: Babu, D, Roy, S. (2013). Left-right asymmetry: cilia stir up new surprises in the node.. Open biology 3 (5) : 130052. ScholarBank@NUS Repository. https://doi.org/10.1098/rsob.130052
Rights: Attribution 4.0 International
Abstract: Cilia are microtubule-based hair-like organelles that project from the surface of most eukaryotic cells. They play critical roles in cellular motility, fluid transport and a variety of signal transduction pathways. While we have a good appreciation of the mechanisms of ciliary biogenesis and the details of their structure, many of their functions demand a more lucid understanding. One such function, which remains as intriguing as the time when it was first discovered, is how beating cilia in the node drive the establishment of left-right asymmetry in the vertebrate embryo. The bone of contention has been the two schools of thought that have been put forth to explain this phenomenon. While the 'morphogen hypothesis' believes that ciliary motility is responsible for the transport of a morphogen preferentially to the left side, the 'two-cilia model' posits that the motile cilia generate a leftward-directed fluid flow that is somehow sensed by the immotile sensory cilia on the periphery of the node. Recent studies with the mouse embryo argue in favour of the latter scenario. Yet this principle may not be generally conserved in other vertebrates that use nodal flow to specify their left-right axis. Work with the teleost fish medaka raises the tantalizing possibility that motility as well as sensory functions of the nodal cilia could be residing within the same organelle. In the end, how ciliary signalling is transmitted to institute asymmetric gene expression that ultimately induces asymmetric organogenesis remains unresolved.
Source Title: Open biology
URI: https://scholarbank.nus.edu.sg/handle/10635/182054
ISSN: 20462441
DOI: 10.1098/rsob.130052
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1098_rsob_130052.pdf2.27 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

53
checked on Oct 16, 2021

Page view(s)

75
checked on Oct 14, 2021

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons