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https://doi.org/10.1186/1748-717X-8-165
Title: | 3D-image-guided high-dose-rate intracavitary brachytherapy for salvage treatment of locally persistent nasopharyngeal carcinoma | Authors: | Ren, Y.-F Cao, X.-P Xu, J Ye, W.-J Gao, Y.-H Teh, B.S Wen, B.-X |
Keywords: | adult aged article brachytherapy cancer control cancer diagnosis cancer staging cancer survival clinical article controlled study cranial nerve paralysis distant metastasis free survival external beam radiotherapy female follow up hearing impairment human human tissue intensity modulated radiation therapy lung metastasis male mucosa inflammation nasopharynx carcinoma neck fibrosis overall survival progression free survival radiation dose retrospective study survival rate temporal lobe necrosis three dimensional imaging treatment planning tumor volume ulcer xerostomia Adult Aged Brachytherapy Disease-Free Survival Female Humans Kaplan-Meier Estimate Male Nasopharyngeal Neoplasms Radiotherapy Planning, Computer-Assisted Retrospective Studies Salvage Therapy |
Issue Date: | 2013 | Citation: | Ren, Y.-F, Cao, X.-P, Xu, J, Ye, W.-J, Gao, Y.-H, Teh, B.S, Wen, B.-X (2013). 3D-image-guided high-dose-rate intracavitary brachytherapy for salvage treatment of locally persistent nasopharyngeal carcinoma. Radiation Oncology 8 (1) : 165. ScholarBank@NUS Repository. https://doi.org/10.1186/1748-717X-8-165 | Rights: | Attribution 4.0 International | Abstract: | Background: To evaluate the therapeutic benefit of 3D-image-guided high-dose-rate intracavitary brachytherapy (3D-image-guided HDR-BT) used as a salvage treatment of intensity modulated radiation therapy (IMRT) in patients with locally persistent nasopharyngeal carcinoma (NPC).Methods: Thirty-two patients with locally persistent NPC after full dose of IMRT were evaluated retrospectively. 3D-image-guided HDR-BT treatment plan was performed on a 3D treatment planning system (PLATO BPS 14.2). The median dose of 16 Gy was delivered to the 100% isodose line of the Gross Tumor Volume.Results: The whole procedure was well tolerated under local anesthesia. The actuarial 5-y local control rate for 3D-image-guided HDR-BT was 93.8%, patients with early-T stage at initial diagnosis had 100% local control rate. The 5-y actuarial progression-free survival and distant metastasis-free survival rate were 78.1%, 87.5%. One patient developed and died of lung metastases. The 5-y actuarial overall survival rate was 96.9%.Conclusions: Our results showed that 3D-image-guided HDR-BT would provide excellent local control as a salvage therapeutic modality to IMRT for patients with locally persistent disease at initial diagnosis of early-T stage NPC. © 2013 Ren et al.; licensee BioMed Central Ltd. | Source Title: | Radiation Oncology | URI: | https://scholarbank.nus.edu.sg/handle/10635/181811 | ISSN: | 1748717X | DOI: | 10.1186/1748-717X-8-165 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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