Please use this identifier to cite or link to this item: https://doi.org/10.3389/fimmu.2013.00286
Title: Lights, camera, and action: Vertebrate skin sets the stage for immune cell interaction with arthropod-vectored pathogens
Authors: Chong, S.Z
Evrard, M
Ng, L.G 
Keywords: CD4+ T lymphocyte
CD8+ T lymphocyte
confocal microscopy
dendritic cell
dendritic epidermal T lymphocyte
dermis
fly bite
host pathogen interaction
human
immune response
immunocompetent cell
innate immunity
insect bite
keratinocyte
Langerhans cell
leishmaniasis
Lutzomyia longipalpis
macrophage
monocyte
multiphoton microscopy
neutrophil
nonhuman
parasite vector
pathogen clearance
Plasmodium
Psychodidae
short survey
skin
T lymphocyte subpopulation
Issue Date: 2013
Citation: Chong, S.Z, Evrard, M, Ng, L.G (2013). Lights, camera, and action: Vertebrate skin sets the stage for immune cell interaction with arthropod-vectored pathogens. Frontiers in Immunology 4 (SEP) : Article 286. ScholarBank@NUS Repository. https://doi.org/10.3389/fimmu.2013.00286
Rights: Attribution 4.0 International
Abstract: Despite increasing studies targeted at host-pathogen interactions, vector-borne diseases remain one of the largest economic health burdens worldwide. Such diseases are vectored by hematophagous arthropods that deposit pathogens into the vertebrate host's skin during a blood meal. These pathogens spend a substantial amount of time in the skin that allows for interaction with cutaneous immune cells, suggesting a window of opportunity for development of vaccine strategies. In particular, the recent availability of intravital imaging approaches has provided further insights into immune cell behavior in living tissues. Here, we discuss how such intravital imaging studies have contributed to our knowledge of cutaneous immune cell behavior and specifically, toward pathogen and tissue trauma from the arthropod bite. We also suggest future imaging approaches that may aid in better understanding of the complex interplay between arthropod-vectored pathogens and cutaneous immunity that could lead to improved therapeutic strategies. © 2013 Chong, Evrard and Ng.
Source Title: Frontiers in Immunology
URI: https://scholarbank.nus.edu.sg/handle/10635/181799
ISSN: 16643224
DOI: 10.3389/fimmu.2013.00286
Rights: Attribution 4.0 International
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