Please use this identifier to cite or link to this item: https://doi.org/10.1155/2014/620423
Title: One patient, two uncommon B-cell neoplasms: Solitary plasmacytoma following complete remission from intravascular large B-cell lymphoma involving central nervous system
Authors: Lee, J
Tan, S.Y 
Tan, L.H.C
Lee, H.Y
Chuah, K.L
Tang, T 
Quek, R 
Tay, K
Tao, M 
Lim, S.T 
Farid, M 
Keywords: CD20 antigen
cyclin D1
cyclophosphamide
doxorubicin
immunoglobulin lambda chain
Ki 67 antigen
lactate dehydrogenase
methotrexate
prednisolone
rituximab
vincristine
adult
antibody labeling
article
bone cancer
bone marrow biopsy
bone plasmacytoma
brain edema
brain radiation
cancer chemotherapy
cancer combination chemotherapy
cancer grading
cancer immunotherapy
cancer radiotherapy
cancer recurrence
cancer regression
case report
cauda equina syndrome
confusion
corticosteroid therapy
drug megadose
flaccid paralysis
germinal center
headache
hemisphere
hospital infection
human
human tissue
immunochemotherapy
immunohistochemistry
immunosuppressive treatment
in situ hybridization
International Prognostic Index
lactate dehydrogenase blood level
large cell lymphoma
lobectomy
male
middle aged
multimodality cancer therapy
neuroimaging
nosocomial pneumonia
nuclear magnetic resonance imaging
occipital lobe
occipital lobotomy
paraplegia
phenotype
plasmacytoma
pneumonia
pons
priority journal
radiation dose fractionation
seizure
Issue Date: 2014
Citation: Lee, J, Tan, S.Y, Tan, L.H.C, Lee, H.Y, Chuah, K.L, Tang, T, Quek, R, Tay, K, Tao, M, Lim, S.T, Farid, M (2014). One patient, two uncommon B-cell neoplasms: Solitary plasmacytoma following complete remission from intravascular large B-cell lymphoma involving central nervous system. Case Reports in Medicine 2014 : 620423. ScholarBank@NUS Repository. https://doi.org/10.1155/2014/620423
Rights: Attribution 4.0 International
Abstract: Second lymphoid neoplasms are an uncommon but recognized feature of non-Hodgkin's lymphomas, putatively arising secondary to common genetic or environmental risk factors. Previous limited evaluations of clonal relatedness between successive mature B-cell malignancies have yielded mixed results. We describe the case of a man with intravascular large B-cell lymphoma involving the central nervous system who went into clinical remission following immunochemotherapy and brain radiation, only to relapse 2 years later with a plasmacytoma of bone causing cauda equina syndrome. The plasmacytoma stained strongly for the cell cycle regulator cyclin D1 on immunohistochemistry, while the original intravascular large cell lymphoma was negative, a disparity providing no support for clonal identity between the 2 neoplasms. Continued efforts atcataloging and evaluating unique associations of B-cell malignancies are critical to improving understanding of overarching disease biology in B-cell malignancies. © 2014 Joycelyn Lee et al.
Source Title: Case Reports in Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/181762
ISSN: 16879627
DOI: 10.1155/2014/620423
Rights: Attribution 4.0 International
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