Please use this identifier to cite or link to this item: https://doi.org/10.1186/1475-2840-13-44
Title: Cardiovascular microRNAs: As modulators and diagnostic biomarkers of diabetic heart disease
Authors: Rawal, S
Manning, P 
Katare, R
Keywords: biological marker
microRNA
microRNA 1
microRNA 126
microRNA 132
microRNA 133
microRNA 208
microRNA 499
unclassified drug
acute heart infarction
angiogenesis
cardiomyopathy
diabetic cardiomyopathy
early diagnosis
heart arrhythmia
heart failure
heart ventricle hypertrophy
human
molecular diagnosis
nonhuman
pathophysiology
prevalence
review
tissue regeneration
Animals
Biological Markers
Cardiovascular Diseases
Diabetes Complications
Diabetes Mellitus
Heart Diseases
Humans
MicroRNAs
Issue Date: 2014
Citation: Rawal, S, Manning, P, Katare, R (2014). Cardiovascular microRNAs: As modulators and diagnostic biomarkers of diabetic heart disease. Cardiovascular Diabetology 13 (1) : 44. ScholarBank@NUS Repository. https://doi.org/10.1186/1475-2840-13-44
Rights: Attribution 4.0 International
Abstract: Diabetic heart disease (DHD) is the leading cause of morbidity and mortality among the people with diabetes, with approximately 80% of the deaths in diabetics are due to cardiovascular complications. Importantly, heart disease in the diabetics develop at a much earlier stage, although remaining asymptomatic till the later stage of the disease, thereby restricting its early detection and active therapeutic management. Thus, a better understanding of the modulators involved in the pathophysiology of DHD is necessary for the early diagnosis and development of novel therapeutic implications for diabetes-associated cardiovascular complications. microRNAs (miRs) have recently been evolved as key players in the various cardiovascular events through the regulation of cardiac gene expression. Besides their credible involvement in controlling the cellular processes, they are also released in to the circulation in disease states where they serve as potential diagnostic biomarkers for cardiovascular disease. However, their potential role in DHD as modulators as well as diagnostic biomarkers is largely unexplored. In this review, we describe the putative mechanisms of the selected cardiovascular miRs in relation to cardiovascular diseases and discuss their possible involvement in the pathophysiology and early diagnosis of DHD. © 2014 Rawal et al.; licensee BioMed Central Ltd.
Source Title: Cardiovascular Diabetology
URI: https://scholarbank.nus.edu.sg/handle/10635/181511
ISSN: 14752840
DOI: 10.1186/1475-2840-13-44
Rights: Attribution 4.0 International
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