Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2334-14-298
Title: A prospective observational study of the prevalence and risk factors for colonization by antibiotic resistant bacteria in patients at admission to hospital in singapore
Authors: Young, B.E
Lye, D.C 
Krishnan, P
Chan, S.P
Leo, Y.S 
Keywords: antibiotic agent
antiinfective agent
adult
article
bacterial colonization
bacterial load
bacterial transmission
bacterium examination
bacterium identification
drug use
extended spectrum beta lactamase producing Enterobacteriaceae
feces analysis
female
hospital admission
hospital patient
hospitalization
human
major clinical study
male
methicillin resistant Staphylococcus aureus
nonhuman
observational study
outpatient care
prediction
predictor variable
prevalence
risk assessment
risk factor
Singapore
tertiary care center
vancomycin resistant Enterococcus
adolescent
aged
antibiotic resistance
Enterobacteriaceae
Enterococcus
hospitalization
infection control
microbiology
middle aged
prospective study
risk factor
Staphylococcal Infections
very elderly
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents
Drug Resistance, Microbial
Enterobacteriaceae
Enterococcus
Female
Hospitalization
Humans
Infection Control
Male
Methicillin-Resistant Staphylococcus aureus
Middle Aged
Prevalence
Prospective Studies
Risk Factors
Singapore
Staphylococcal Infections
Issue Date: 2014
Citation: Young, B.E, Lye, D.C, Krishnan, P, Chan, S.P, Leo, Y.S (2014). A prospective observational study of the prevalence and risk factors for colonization by antibiotic resistant bacteria in patients at admission to hospital in singapore. BMC Infectious Diseases 14 (1) : 298. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2334-14-298
Rights: Attribution 4.0 International
Abstract: Background: Drug resistant organisms pose an increasing threat to the successful treatment of common infections. Understanding colonization patterns of these bacteria is important for effective antibiotic treatment and infection control guidelines.Methods: A prospective observational study was performed to determine the prevalence of colonization with extended-spectrum ?-lactamase-producing Enterobacteriaceae (ESBL-E), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) among patients admitted via the emergency department to a public tertiary hospital in Singapore. Anterior nares, groin, axillary and rectal swabs were collected at admission and cultured using standard bacteriological techniques. Clinical data including healthcare contact within the past 12 months and recent antibiotic use was collected and analyzed using a logistic regression model.Results: 1006 patients were screened. 124 (12.4%) were colonized by ESBL-E, 18 (1.8%) by MRSA while no VRE was detected. Antibiotic use within the past month was the only significant predictor for ESBL-E colonization in the regression model, with an adjusted odds ratio (AOR) of 2.58 (1.04 to 6.42). In participants recently prescribed antibiotics and hospitalized in the previous 3 months, 29.4% were colonized by ESBL-E. This represented 20.2% of the total ESBL-E burden, and ESBL-E was also detected in 6.3% of participants with no healthcare contact. Hospitalization and outpatient hospital visits predicted MRSA colonization in the univariate analysis. Neither was statistically significant in the logistic regression model, with AORs for MRSA colonization following hospitalization in the past 3 and 12 months of 3.81 [95% CI 0.84-17.28] and 3.48 [0.64-18.92] respectively.Conclusion: A high prevalence of colonization with ESBL-E was evident among patients at admission, even in the absence of recent antibiotic use or contact with healthcare. © 2014 Young et al.; licensee BioMed Central Ltd.
Source Title: BMC Infectious Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/181499
ISSN: 14712334
DOI: 10.1186/1471-2334-14-298
Rights: Attribution 4.0 International
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