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https://doi.org/10.1186/s13075-014-0471-7
Title: | Regulatory T cells and control of the germinal centre response | Authors: | Vanderleyden, I Linterman, M.A Smith, K.G.C |
Keywords: | transcription factor FOXP3 cytotoxic T lymphocyte antigen 4 forkhead transcription factor FOXP3 protein, human autoimmunity B lymphocyte differentiation binding affinity CD4+ T lymphocyte cell clone cell expansion cell selection follicular helper T cell follicular regulatory T cell Foxp3+ regulatory T cell germinal center helper cell human immunological tolerance immunoregulation infection prevention lymphocyte function memory cell plasma cell protein expression regulatory T lymphocyte Review T lymphocyte subpopulation animal B lymphocyte biological model cell differentiation germinal center immunology metabolism regulatory T lymphocyte Animals B-Lymphocytes Cell Differentiation CTLA-4 Antigen Forkhead Transcription Factors Germinal Center Humans Models, Immunological Plasma Cells T-Lymphocytes, Regulatory |
Issue Date: | 2014 | Citation: | Vanderleyden, I, Linterman, M.A, Smith, K.G.C (2014). Regulatory T cells and control of the germinal centre response. Arthritis Research and Therapy 16 (1) : 471. ScholarBank@NUS Repository. https://doi.org/10.1186/s13075-014-0471-7 | Rights: | Attribution 4.0 International | Abstract: | Germinal centres (GCs) are specialised lymphoid microenvironments that form in secondary B-cell follicles upon exposure to T-dependent antigens. In the GC, clonal expansion, selection and differentiation of GC B cells result in the production of high-affinity plasma cells and memory B cells that provide protection against subsequent infection. The GC is carefully regulated to fulfil its critical role in defence against infection and to ensure that immunological tolerance is not broken in the process. The GC response can be controlled by a number of mechanisms, one of which is by forkhead box p3 expressing regulatory T (Treg) cells, a suppressive population of CD4+ T cells. A specialised subset of Treg cells - follicular regulatory T (Tfr) cells - form after immunisation and are able to access the GC, where they control the size and output of the response. Our knowledge of Treg cell control of the GC is expanding. In this review we will discuss recent advances in the field, with a particular emphasis on the differentiation and function of Tfr cells in the GC. © 2014 Vanderleyden et al. | Source Title: | Arthritis Research and Therapy | URI: | https://scholarbank.nus.edu.sg/handle/10635/181480 | ISSN: | 14786354 | DOI: | 10.1186/s13075-014-0471-7 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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