Please use this identifier to cite or link to this item: https://doi.org/10.3389/fncir.2015.00087
Title: Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior
Authors: Lin, H.-C
Pan, H.-C
Lin, S.-H
Lo, Y.-C
Shen, E.T.-H
Liao, L.-D 
Liao, P.-H
Chien, Y.-W
Liao, K.-D
Jaw, F.-S
Chu, K.-W
Lai, H.-Y
Chen, Y.-Y
Keywords: cholinergic receptor
dopamine 2 receptor
dopamine receptor
nicotinic receptor alpha4
protein c fos
dopamine 2 receptor
DRD2 protein, rat
nicotinic acetylcholine receptor alpha4 subunit
nicotinic receptor
protein c fos
adult
alpha rhythm
animal experiment
animal tissue
Article
beta rhythm
brain depth stimulation
brain function
central thalamic deep brain stimulation
cholinergic system
cognition
connectome
controlled study
corpus striatum
delta rhythm
dopaminergic system
male
nerve cell plasticity
neuromodulation
nonhuman
oscillation
protein expression
rat
thalamus
thalamus lateral nucleus
theta rhythm
animal
brain depth stimulation
cognition
corpus striatum
hemispheric dominance
hippocampus
learning
metabolism
nerve tract
neuropsychological test
physiology
procedures
reward
Sprague Dawley rat
thalamus
Alpha Rhythm
Animals
Cognition
Corpus Striatum
Deep Brain Stimulation
Functional Laterality
Hippocampus
Learning
Male
Neural Pathways
Neuropsychological Tests
Proto-Oncogene Proteins c-fos
Rats, Sprague-Dawley
Receptors, Dopamine D2
Receptors, Nicotinic
Reward
Thalamus
Theta Rhythm
Issue Date: 2016
Citation: Lin, H.-C, Pan, H.-C, Lin, S.-H, Lo, Y.-C, Shen, E.T.-H, Liao, L.-D, Liao, P.-H, Chien, Y.-W, Liao, K.-D, Jaw, F.-S, Chu, K.-W, Lai, H.-Y, Chen, Y.-Y (2016). Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior. Frontiers in Neural Circuits 9 (42370) : 87. ScholarBank@NUS Repository. https://doi.org/10.3389/fncir.2015.00087
Rights: Attribution 4.0 International
Abstract: Central thalamic deep brain stimulation (CT-DBS) has been proposed as an experimental therapeutic approach to produce consistent sustained regulation of forebrain arousal for several neurological diseases. We investigated local field potentials (LFPs) induced by CT-DBS from the thalamic central lateral nuclei (CL) and the striatum as potential biomarkers for the enhancement of lever-pressing skill learning. LFPs were simultaneously recorded from multiple sites in the CL, ventral striatum (Vstr), and dorsal striatum (Dstr). LFP oscillation power and functional connectivity were assessed and compared between the CT-DBS and sham control groups. The theta and alpha LFP oscillations were significantly increased in the CL and striatum in the CT-DBS group. Furthermore, interhemispheric coherences between bilateral CL and striatum were increased in the theta band. Additionally, enhancement of c-Fos activity, dopamine D2 receptor (Drd2), and ?4-nicotinic acetylcholine receptor (?4-nAChR) occurred after CT-DBS treatment in the striatum and hippocampus. CT-DBS strengthened thalamic-striatal functional connectivity, which demonstrates that the inter-regional connectivity enhancement might contribute to synaptic plasticity in the striatum. Altered dopaminergic and cholinergic receptors resulted in modulation of striatal synaptic plasticity's ability to regulate downstream signaling cascades for higher brain functions of lever-pressing skill learning. © 2016 Lin, Pan, Lin, Lo, Shen, Liao, Liao, Chien, Liao, Jaw, Chu, Lai and Chen.
Source Title: Frontiers in Neural Circuits
URI: https://scholarbank.nus.edu.sg/handle/10635/181399
ISSN: 16625110
DOI: 10.3389/fncir.2015.00087
Rights: Attribution 4.0 International
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