Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fncir.2015.00087
DC Field | Value | |
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dc.title | Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior | |
dc.contributor.author | Lin, H.-C | |
dc.contributor.author | Pan, H.-C | |
dc.contributor.author | Lin, S.-H | |
dc.contributor.author | Lo, Y.-C | |
dc.contributor.author | Shen, E.T.-H | |
dc.contributor.author | Liao, L.-D | |
dc.contributor.author | Liao, P.-H | |
dc.contributor.author | Chien, Y.-W | |
dc.contributor.author | Liao, K.-D | |
dc.contributor.author | Jaw, F.-S | |
dc.contributor.author | Chu, K.-W | |
dc.contributor.author | Lai, H.-Y | |
dc.contributor.author | Chen, Y.-Y | |
dc.date.accessioned | 2020-10-27T10:48:28Z | |
dc.date.available | 2020-10-27T10:48:28Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Lin, H.-C, Pan, H.-C, Lin, S.-H, Lo, Y.-C, Shen, E.T.-H, Liao, L.-D, Liao, P.-H, Chien, Y.-W, Liao, K.-D, Jaw, F.-S, Chu, K.-W, Lai, H.-Y, Chen, Y.-Y (2016). Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior. Frontiers in Neural Circuits 9 (42370) : 87. ScholarBank@NUS Repository. https://doi.org/10.3389/fncir.2015.00087 | |
dc.identifier.issn | 16625110 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/181399 | |
dc.description.abstract | Central thalamic deep brain stimulation (CT-DBS) has been proposed as an experimental therapeutic approach to produce consistent sustained regulation of forebrain arousal for several neurological diseases. We investigated local field potentials (LFPs) induced by CT-DBS from the thalamic central lateral nuclei (CL) and the striatum as potential biomarkers for the enhancement of lever-pressing skill learning. LFPs were simultaneously recorded from multiple sites in the CL, ventral striatum (Vstr), and dorsal striatum (Dstr). LFP oscillation power and functional connectivity were assessed and compared between the CT-DBS and sham control groups. The theta and alpha LFP oscillations were significantly increased in the CL and striatum in the CT-DBS group. Furthermore, interhemispheric coherences between bilateral CL and striatum were increased in the theta band. Additionally, enhancement of c-Fos activity, dopamine D2 receptor (Drd2), and ?4-nicotinic acetylcholine receptor (?4-nAChR) occurred after CT-DBS treatment in the striatum and hippocampus. CT-DBS strengthened thalamic-striatal functional connectivity, which demonstrates that the inter-regional connectivity enhancement might contribute to synaptic plasticity in the striatum. Altered dopaminergic and cholinergic receptors resulted in modulation of striatal synaptic plasticity's ability to regulate downstream signaling cascades for higher brain functions of lever-pressing skill learning. © 2016 Lin, Pan, Lin, Lo, Shen, Liao, Liao, Chien, Liao, Jaw, Chu, Lai and Chen. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | cholinergic receptor | |
dc.subject | dopamine 2 receptor | |
dc.subject | dopamine receptor | |
dc.subject | nicotinic receptor alpha4 | |
dc.subject | protein c fos | |
dc.subject | dopamine 2 receptor | |
dc.subject | DRD2 protein, rat | |
dc.subject | nicotinic acetylcholine receptor alpha4 subunit | |
dc.subject | nicotinic receptor | |
dc.subject | protein c fos | |
dc.subject | adult | |
dc.subject | alpha rhythm | |
dc.subject | animal experiment | |
dc.subject | animal tissue | |
dc.subject | Article | |
dc.subject | beta rhythm | |
dc.subject | brain depth stimulation | |
dc.subject | brain function | |
dc.subject | central thalamic deep brain stimulation | |
dc.subject | cholinergic system | |
dc.subject | cognition | |
dc.subject | connectome | |
dc.subject | controlled study | |
dc.subject | corpus striatum | |
dc.subject | delta rhythm | |
dc.subject | dopaminergic system | |
dc.subject | male | |
dc.subject | nerve cell plasticity | |
dc.subject | neuromodulation | |
dc.subject | nonhuman | |
dc.subject | oscillation | |
dc.subject | protein expression | |
dc.subject | rat | |
dc.subject | thalamus | |
dc.subject | thalamus lateral nucleus | |
dc.subject | theta rhythm | |
dc.subject | animal | |
dc.subject | brain depth stimulation | |
dc.subject | cognition | |
dc.subject | corpus striatum | |
dc.subject | hemispheric dominance | |
dc.subject | hippocampus | |
dc.subject | learning | |
dc.subject | metabolism | |
dc.subject | nerve tract | |
dc.subject | neuropsychological test | |
dc.subject | physiology | |
dc.subject | procedures | |
dc.subject | reward | |
dc.subject | Sprague Dawley rat | |
dc.subject | thalamus | |
dc.subject | Alpha Rhythm | |
dc.subject | Animals | |
dc.subject | Cognition | |
dc.subject | Corpus Striatum | |
dc.subject | Deep Brain Stimulation | |
dc.subject | Functional Laterality | |
dc.subject | Hippocampus | |
dc.subject | Learning | |
dc.subject | Male | |
dc.subject | Neural Pathways | |
dc.subject | Neuropsychological Tests | |
dc.subject | Proto-Oncogene Proteins c-fos | |
dc.subject | Rats, Sprague-Dawley | |
dc.subject | Receptors, Dopamine D2 | |
dc.subject | Receptors, Nicotinic | |
dc.subject | Reward | |
dc.subject | Thalamus | |
dc.subject | Theta Rhythm | |
dc.type | Article | |
dc.contributor.department | LIFE SCIENCES INSTITUTE | |
dc.description.doi | 10.3389/fncir.2015.00087 | |
dc.description.sourcetitle | Frontiers in Neural Circuits | |
dc.description.volume | 9 | |
dc.description.issue | 42370 | |
dc.description.page | 87 | |
Appears in Collections: | Elements Staff Publications |
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