Please use this identifier to cite or link to this item:
https://doi.org/10.1111/acel.12585
| Title: | The DrugAge database of aging-related drugs | Authors: | Barardo, D Thornton, D Thoppil, H Walsh, M Sharifi, S Ferreira, S Anži?, A Fernandes, M Monteiro, P Grum, T Cordeiro, R De-Souza, E.A Budovsky, A Araujo, N Gruber, J Petrascheck, M Fraifeld, V.E Zhavoronkov, A Moskalev, A de Magalhães, J.P |
Keywords: | drug glutathione agents affecting water, molecule or ion transport antioxidant aging antioxidant activity Article drug database human ion transport life extension longevity nonhuman priority journal aging animal biology Caenorhabditis elegans chemistry computer interface Drosophila melanogaster drug effects genetics geriatrics growth, development and aging metabolism mouse procedures Saccharomyces cerevisiae Aging Animals Antioxidants Caenorhabditis elegans Computational Biology Databases, Pharmaceutical Drosophila melanogaster Geriatrics Humans Membrane Transport Modulators Metabolic Networks and Pathways Mice Saccharomyces cerevisiae User-Computer Interface |
Issue Date: | 2017 | Citation: | Barardo, D, Thornton, D, Thoppil, H, Walsh, M, Sharifi, S, Ferreira, S, Anži?, A, Fernandes, M, Monteiro, P, Grum, T, Cordeiro, R, De-Souza, E.A, Budovsky, A, Araujo, N, Gruber, J, Petrascheck, M, Fraifeld, V.E, Zhavoronkov, A, Moskalev, A, de Magalhães, J.P (2017). The DrugAge database of aging-related drugs. Aging Cell 16 (3) : 594-597. ScholarBank@NUS Repository. https://doi.org/10.1111/acel.12585 | Rights: | Attribution 4.0 International | Abstract: | Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug–gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. | Source Title: | Aging Cell | URI: | https://scholarbank.nus.edu.sg/handle/10635/181275 | ISSN: | 14749718 | DOI: | 10.1111/acel.12585 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
| File | Description | Size | Format | Access Settings | Version | |
|---|---|---|---|---|---|---|
| 10_1111_acel_12585.pdf | 632.07 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License
