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Please use this identifier to cite or link to this item: https://doi.org/10.1111/acel.12585
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dc.titleThe DrugAge database of aging-related drugs
dc.contributor.authorBarardo, D
dc.contributor.authorThornton, D
dc.contributor.authorThoppil, H
dc.contributor.authorWalsh, M
dc.contributor.authorSharifi, S
dc.contributor.authorFerreira, S
dc.contributor.authorAnži?, A
dc.contributor.authorFernandes, M
dc.contributor.authorMonteiro, P
dc.contributor.authorGrum, T
dc.contributor.authorCordeiro, R
dc.contributor.authorDe-Souza, E.A
dc.contributor.authorBudovsky, A
dc.contributor.authorAraujo, N
dc.contributor.authorGruber, J
dc.contributor.authorPetrascheck, M
dc.contributor.authorFraifeld, V.E
dc.contributor.authorZhavoronkov, A
dc.contributor.authorMoskalev, A
dc.contributor.authorde Magalhães, J.P
dc.date.accessioned2020-10-27T10:25:47Z
dc.date.available2020-10-27T10:25:47Z
dc.date.issued2017
dc.identifier.citationBarardo, D, Thornton, D, Thoppil, H, Walsh, M, Sharifi, S, Ferreira, S, Anži?, A, Fernandes, M, Monteiro, P, Grum, T, Cordeiro, R, De-Souza, E.A, Budovsky, A, Araujo, N, Gruber, J, Petrascheck, M, Fraifeld, V.E, Zhavoronkov, A, Moskalev, A, de Magalhães, J.P (2017). The DrugAge database of aging-related drugs. Aging Cell 16 (3) : 594-597. ScholarBank@NUS Repository. https://doi.org/10.1111/acel.12585
dc.identifier.issn14749718
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181275
dc.description.abstractAging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug–gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectdrug
dc.subjectglutathione
dc.subjectagents affecting water, molecule or ion transport
dc.subjectantioxidant
dc.subjectaging
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectdrug database
dc.subjecthuman
dc.subjection transport
dc.subjectlife extension
dc.subjectlongevity
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectaging
dc.subjectanimal
dc.subjectbiology
dc.subjectCaenorhabditis elegans
dc.subjectchemistry
dc.subjectcomputer interface
dc.subjectDrosophila melanogaster
dc.subjectdrug effects
dc.subjectgenetics
dc.subjectgeriatrics
dc.subjectgrowth, development and aging
dc.subjectmetabolism
dc.subjectmouse
dc.subjectprocedures
dc.subjectSaccharomyces cerevisiae
dc.subjectAging
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectCaenorhabditis elegans
dc.subjectComputational Biology
dc.subjectDatabases, Pharmaceutical
dc.subjectDrosophila melanogaster
dc.subjectGeriatrics
dc.subjectHumans
dc.subjectMembrane Transport Modulators
dc.subjectMetabolic Networks and Pathways
dc.subjectMice
dc.subjectSaccharomyces cerevisiae
dc.subjectUser-Computer Interface
dc.typeArticle
dc.contributor.departmentYALE-NUS COLLEGE
dc.description.doi10.1111/acel.12585
dc.description.sourcetitleAging Cell
dc.description.volume16
dc.description.issue3
dc.description.page594-597
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