Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12885-019-5302-4
Title: Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy
Authors: Molassiotis, A
Cheng, H.L
Lopez, V 
Au, J.S.K
Chan, A 
Bandla, A 
Leung, K.T
Li, Y.C
Wong, K.H
Suen, L.K.P
Chan, C.W
Yorke, J
Farrell, C
Sundar, R
Keywords: carboplatin
cisplatin
docetaxel
oxaliplatin
paclitaxel
platinum derivative
taxane derivative
antineoplastic agent
adult
aged
Article
clinical assessment
clinical feature
clinical practice
cohort analysis
controlled study
correlation analysis
disease course
disease severity
female
human
incidence
longitudinal study
major clinical study
male
middle aged
motor neuropathy
multiple cycle treatment
nerve conduction
observational study
patient-reported outcome
peripheral neuropathy
prevalence
prospective study
rating scale
sensory neuropathy
cancer staging
clinical trial
complication
dose response
multicenter study
neoplasm
peripheral neuropathy
quality of life
severity of illness index
very elderly
Adult
Aged
Aged, 80 and over
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Cohort Studies
Dose-Response Relationship, Drug
Female
Humans
Longitudinal Studies
Male
Middle Aged
Neoplasm Staging
Neoplasms
Patient Reported Outcome Measures
Peripheral Nervous System Diseases
Prevalence
Prospective Studies
Quality of Life
Severity of Illness Index
Issue Date: 2019
Citation: Molassiotis, A, Cheng, H.L, Lopez, V, Au, J.S.K, Chan, A, Bandla, A, Leung, K.T, Li, Y.C, Wong, K.H, Suen, L.K.P, Chan, C.W, Yorke, J, Farrell, C, Sundar, R (2019). Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy. BMC Cancer 19 (1) : 132. ScholarBank@NUS Repository. https://doi.org/10.1186/s12885-019-5302-4
Rights: Attribution 4.0 International
Abstract: Background: There are inconsistencies in the literature regarding the prevalence and assessment of chemotherapy-induced peripheral neuropathy (CIPN). This study explored CIPN natural history and its characteristics in patients receiving taxane- and platinum-based chemotherapy. Patients and methods: Multi-country multisite prospective longitudinal observational study. Patients were assessed before commencing and three weekly during chemotherapy for up to six cycles, and at 6,9, and 12 months using clinician-based scales (NCI-CTCAE; WHO-CIPN criterion), objective assessments (cotton wool test;10 g monofilament); patient-reported outcome measures (FACT/GOG-Ntx; EORTC-CIPN20), and Nerve Conduction Studies. Results: In total, 343 patients were recruited in the cohort, providing 2399 observations. There was wide variation in CIPN prevalence rates using different assessments (14.2-53.4%). Prevalence of sensory neuropathy (and associated symptom profile) was also different in each type of chemotherapy, with paclitaxel (up to 63%) and oxaliplatin (up to 71.4%) showing the highest CIPN rates in most assessments and a more complex symptom profile. Peak prevalence was around the 6-month assessment (up to 71.4%). Motor neurotoxicity was common, particularly in the docetaxel subgroup (up to 22.1%; detected by NCI-CTCAE). There were relatively moderately-to-low correlations between scales (r s = 0.15,p < 0.05-r s = 0.48 p < 0.001), suggesting that they measure different neurotoxicity aspects from each other. Cumulative chemotherapy dose was not associated with onset and course of CIPN. Conclusion: The historical variation reported in CIPN incidence and prevalence is possibly confounded by disagreement between assessment modalities. Clinical practice should consider assessment of motor neuropathy for neurotoxic chemotherapy. Current scales may not be all appropriate to measure CIPN in a valid way, and a combination of scales are needed. © 2019 The Author(s).
Source Title: BMC Cancer
URI: https://scholarbank.nus.edu.sg/handle/10635/181161
ISSN: 14712407
DOI: 10.1186/s12885-019-5302-4
Rights: Attribution 4.0 International
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