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https://doi.org/10.1242/jcs.01034
| Title: | Genetic characterization of the Drosophila homologue of coronin | Authors: | Bharathi, V Pallavi, S.K Bajpai, R Emerald, B.S Shashidhara, L.S |
Keywords: | actin actin binding protein decapentaplegic protein F actin green fluorescent protein hybrid protein khellin membrane protein morphogen syntaxin unclassified drug allele animal cell anterior posterior axis article cell junction coated vesicle controlled study cytoskeleton Drosophila endocytosis epithelium cell exocytosis eye development forelimb gene disruption gene interaction gene mutation gene overexpression genetic analysis genetic association genetic linkage homozygosity imaginal disc limb development membrane transport molecular cloning nonhuman nucleotide sequence phenotype priority journal protein localization sequence homology 5' Untranslated Regions Actins Alleles Amino Acid Sequence Animals Antigens, Surface Blotting, Northern Cell Membrane Cloning, Molecular Cytoskeleton Down-Regulation Drosophila melanogaster Drosophila Proteins Endocytosis Epithelial Cells Exocytosis Gene Expression Regulation, Developmental Green Fluorescent Proteins Homozygote Microfilament Proteins Models, Genetic Molecular Sequence Data Mutation Nerve Tissue Proteins Phenotype Protein Binding Recombinant Fusion Proteins RNA RNA, Messenger Signal Transduction Syntaxin 1 Tissue Distribution Wing Animalia Drosophila melanogaster Hexapoda Melanogaster |
Issue Date: | 2004 | Citation: | Bharathi, V, Pallavi, S.K, Bajpai, R, Emerald, B.S, Shashidhara, L.S (2004). Genetic characterization of the Drosophila homologue of coronin. Journal of Cell Science 117 (10) : 1911-1922. ScholarBank@NUS Repository. https://doi.org/10.1242/jcs.01034 | Rights: | Attribution 4.0 International | Abstract: | We report cloning and characterization of coro, which codes for the Drosophila homologue of the F-actin binding protein coronin. Viable alleles of coro produce a variety of phenotypes in leg, wing and eye development, which are similar to the phenotypes observed as a result of mutations in genes associated with the actin cytoskeleton and/or membrane trafficking. Homozygous lethal mutations in coro results in the disruption of the actin cytoskeleton in wing imaginal discs. Formation of both basolateral septate junctions and apical adherens junctions are also adversely affected in epithelial cells. Both viable and lethal alleles of coro show genetic interactions with syntaxin1A, a gene required for membrane trafficking. They also show enhanced response to over-expression of Decapentaplegic (Dpp) and its receptor Thick vein. Tracing of Dpp morphogen using a Dpp | Source Title: | Journal of Cell Science | URI: | https://scholarbank.nus.edu.sg/handle/10635/181110 | ISSN: | 00219533 | DOI: | 10.1242/jcs.01034 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Elements Staff Publications |
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