Please use this identifier to cite or link to this item: https://doi.org/10.1242/jcs.01034
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dc.titleGenetic characterization of the Drosophila homologue of coronin
dc.contributor.authorBharathi, V
dc.contributor.authorPallavi, S.K
dc.contributor.authorBajpai, R
dc.contributor.authorEmerald, B.S
dc.contributor.authorShashidhara, L.S
dc.date.accessioned2020-10-27T09:52:21Z
dc.date.available2020-10-27T09:52:21Z
dc.date.issued2004
dc.identifier.citationBharathi, V, Pallavi, S.K, Bajpai, R, Emerald, B.S, Shashidhara, L.S (2004). Genetic characterization of the Drosophila homologue of coronin. Journal of Cell Science 117 (10) : 1911-1922. ScholarBank@NUS Repository. https://doi.org/10.1242/jcs.01034
dc.identifier.issn00219533
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181110
dc.description.abstractWe report cloning and characterization of coro, which codes for the Drosophila homologue of the F-actin binding protein coronin. Viable alleles of coro produce a variety of phenotypes in leg, wing and eye development, which are similar to the phenotypes observed as a result of mutations in genes associated with the actin cytoskeleton and/or membrane trafficking. Homozygous lethal mutations in coro results in the disruption of the actin cytoskeleton in wing imaginal discs. Formation of both basolateral septate junctions and apical adherens junctions are also adversely affected in epithelial cells. Both viable and lethal alleles of coro show genetic interactions with syntaxin1A, a gene required for membrane trafficking. They also show enhanced response to over-expression of Decapentaplegic (Dpp) and its receptor Thick vein. Tracing of Dpp morphogen using a Dpp
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectactin
dc.subjectactin binding protein
dc.subjectdecapentaplegic protein
dc.subjectF actin
dc.subjectgreen fluorescent protein
dc.subjecthybrid protein
dc.subjectkhellin
dc.subjectmembrane protein
dc.subjectmorphogen
dc.subjectsyntaxin
dc.subjectunclassified drug
dc.subjectallele
dc.subjectanimal cell
dc.subjectanterior posterior axis
dc.subjectarticle
dc.subjectcell junction
dc.subjectcoated vesicle
dc.subjectcontrolled study
dc.subjectcytoskeleton
dc.subjectDrosophila
dc.subjectendocytosis
dc.subjectepithelium cell
dc.subjectexocytosis
dc.subjecteye development
dc.subjectforelimb
dc.subjectgene disruption
dc.subjectgene interaction
dc.subjectgene mutation
dc.subjectgene overexpression
dc.subjectgenetic analysis
dc.subjectgenetic association
dc.subjectgenetic linkage
dc.subjecthomozygosity
dc.subjectimaginal disc
dc.subjectlimb development
dc.subjectmembrane transport
dc.subjectmolecular cloning
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectphenotype
dc.subjectpriority journal
dc.subjectprotein localization
dc.subjectsequence homology
dc.subject5' Untranslated Regions
dc.subjectActins
dc.subjectAlleles
dc.subjectAmino Acid Sequence
dc.subjectAnimals
dc.subjectAntigens, Surface
dc.subjectBlotting, Northern
dc.subjectCell Membrane
dc.subjectCloning, Molecular
dc.subjectCytoskeleton
dc.subjectDown-Regulation
dc.subjectDrosophila melanogaster
dc.subjectDrosophila Proteins
dc.subjectEndocytosis
dc.subjectEpithelial Cells
dc.subjectExocytosis
dc.subjectGene Expression Regulation, Developmental
dc.subjectGreen Fluorescent Proteins
dc.subjectHomozygote
dc.subjectMicrofilament Proteins
dc.subjectModels, Genetic
dc.subjectMolecular Sequence Data
dc.subjectMutation
dc.subjectNerve Tissue Proteins
dc.subjectPhenotype
dc.subjectProtein Binding
dc.subjectRecombinant Fusion Proteins
dc.subjectRNA
dc.subjectRNA, Messenger
dc.subjectSignal Transduction
dc.subjectSyntaxin 1
dc.subjectTissue Distribution
dc.subjectWing
dc.subjectAnimalia
dc.subjectDrosophila melanogaster
dc.subjectHexapoda
dc.subjectMelanogaster
dc.typeArticle
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.description.doi10.1242/jcs.01034
dc.description.sourcetitleJournal of Cell Science
dc.description.volume117
dc.description.issue10
dc.description.page1911-1922
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