Please use this identifier to cite or link to this item: https://doi.org/10.1242/jcs.01034
Title: Genetic characterization of the Drosophila homologue of coronin
Authors: Bharathi, V
Pallavi, S.K
Bajpai, R
Emerald, B.S 
Shashidhara, L.S
Keywords: actin
actin binding protein
decapentaplegic protein
F actin
green fluorescent protein
hybrid protein
khellin
membrane protein
morphogen
syntaxin
unclassified drug
allele
animal cell
anterior posterior axis
article
cell junction
coated vesicle
controlled study
cytoskeleton
Drosophila
endocytosis
epithelium cell
exocytosis
eye development
forelimb
gene disruption
gene interaction
gene mutation
gene overexpression
genetic analysis
genetic association
genetic linkage
homozygosity
imaginal disc
limb development
membrane transport
molecular cloning
nonhuman
nucleotide sequence
phenotype
priority journal
protein localization
sequence homology
5' Untranslated Regions
Actins
Alleles
Amino Acid Sequence
Animals
Antigens, Surface
Blotting, Northern
Cell Membrane
Cloning, Molecular
Cytoskeleton
Down-Regulation
Drosophila melanogaster
Drosophila Proteins
Endocytosis
Epithelial Cells
Exocytosis
Gene Expression Regulation, Developmental
Green Fluorescent Proteins
Homozygote
Microfilament Proteins
Models, Genetic
Molecular Sequence Data
Mutation
Nerve Tissue Proteins
Phenotype
Protein Binding
Recombinant Fusion Proteins
RNA
RNA, Messenger
Signal Transduction
Syntaxin 1
Tissue Distribution
Wing
Animalia
Drosophila melanogaster
Hexapoda
Melanogaster
Issue Date: 2004
Citation: Bharathi, V, Pallavi, S.K, Bajpai, R, Emerald, B.S, Shashidhara, L.S (2004). Genetic characterization of the Drosophila homologue of coronin. Journal of Cell Science 117 (10) : 1911-1922. ScholarBank@NUS Repository. https://doi.org/10.1242/jcs.01034
Rights: Attribution 4.0 International
Abstract: We report cloning and characterization of coro, which codes for the Drosophila homologue of the F-actin binding protein coronin. Viable alleles of coro produce a variety of phenotypes in leg, wing and eye development, which are similar to the phenotypes observed as a result of mutations in genes associated with the actin cytoskeleton and/or membrane trafficking. Homozygous lethal mutations in coro results in the disruption of the actin cytoskeleton in wing imaginal discs. Formation of both basolateral septate junctions and apical adherens junctions are also adversely affected in epithelial cells. Both viable and lethal alleles of coro show genetic interactions with syntaxin1A, a gene required for membrane trafficking. They also show enhanced response to over-expression of Decapentaplegic (Dpp) and its receptor Thick vein. Tracing of Dpp morphogen using a Dpp
Source Title: Journal of Cell Science
URI: https://scholarbank.nus.edu.sg/handle/10635/181110
ISSN: 00219533
DOI: 10.1242/jcs.01034
Rights: Attribution 4.0 International
Appears in Collections:Elements
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