Please use this identifier to cite or link to this item: https://doi.org/10.3201/eid1508.081486
Title: Entomologic and virologic investigation of chikungunya, Singapore
Authors: Ng, L.-C
Tan, L.-K
Tan, C.-H
Tan, S.S.Y
Hapuarachchi, H.C
Pok, K.-Y
Lai, Y.-L
Lam-Phua, S.-G
Bucht, G
Lin, R.T.P 
Leo, Y.-S 
Tan, B.-H
Han, H.-K
Ooi, P.-L.S
James, L
Khoo, S.-P
Keywords: alanine
glycoprotein E1
valine
virus RNA
Aedes aegypti
Aedes albopictus
Africa
amino acid substitution
article
Chikungunya alphavirus
controlled study
disease surveillance
DNA sequence
epidemic
gene e1
genotype
geographic distribution
human
infection control
major clinical study
nonhuman
nucleotide sequence
phylogeny
Singapore
vector control
virus gene
virus infection
wild type
Aedes
Alphavirus Infections
Amino Acid Substitution
Animals
Base Sequence
Chikungunya virus
Communicable Diseases, Emerging
Disease Outbreaks
DNA Primers
DNA, Viral
Genes, env
Humans
Insect Vectors
Molecular Epidemiology
Phylogeny
Singapore
Viral Envelope Proteins
Issue Date: 2009
Citation: Ng, L.-C, Tan, L.-K, Tan, C.-H, Tan, S.S.Y, Hapuarachchi, H.C, Pok, K.-Y, Lai, Y.-L, Lam-Phua, S.-G, Bucht, G, Lin, R.T.P, Leo, Y.-S, Tan, B.-H, Han, H.-K, Ooi, P.-L.S, James, L, Khoo, S.-P (2009). Entomologic and virologic investigation of chikungunya, Singapore. Emerging Infectious Diseases 15 (8) : 1243-1249. ScholarBank@NUS Repository. https://doi.org/10.3201/eid1508.081486
Rights: Attribution 4.0 International
Abstract: Local transmission of chikungunya, a debilitating mosquito-borne viral disease, was first reported in Singapore in January 2008. After 3 months of absence, locally acquired Chikungunya cases resurfaced in May 2008, causing an outbreak that resulted in a total of 231 cases by September 2008. The circulating viruses were related to East, Central, and South African genotypes that emerged in the Indian Ocean region in 2005. The first local outbreak was due to a wild-type virus (alanine at codon 226 of the envelope 1 gene) and occurred in an area where Aedes aegypti mosquitoes were the primary vector. Strains isolated during subsequent outbreaks showed alanine to valine substitution (A226V) and largely spread in areas predominated by Ae. albopictus mosquitoes. These findings led to a revision of the current vector control strategy in Singapore. This report highlights the use of entomologic and virologic data to assist in the control of chikungunya in disease-endemic areas.
Source Title: Emerging Infectious Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/181010
ISSN: 10806040
DOI: 10.3201/eid1508.081486
Rights: Attribution 4.0 International
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