Please use this identifier to cite or link to this item: https://doi.org/10.3201/eid1508.081486
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dc.titleEntomologic and virologic investigation of chikungunya, Singapore
dc.contributor.authorNg, L.-C
dc.contributor.authorTan, L.-K
dc.contributor.authorTan, C.-H
dc.contributor.authorTan, S.S.Y
dc.contributor.authorHapuarachchi, H.C
dc.contributor.authorPok, K.-Y
dc.contributor.authorLai, Y.-L
dc.contributor.authorLam-Phua, S.-G
dc.contributor.authorBucht, G
dc.contributor.authorLin, R.T.P
dc.contributor.authorLeo, Y.-S
dc.contributor.authorTan, B.-H
dc.contributor.authorHan, H.-K
dc.contributor.authorOoi, P.-L.S
dc.contributor.authorJames, L
dc.contributor.authorKhoo, S.-P
dc.date.accessioned2020-10-27T06:53:35Z
dc.date.available2020-10-27T06:53:35Z
dc.date.issued2009
dc.identifier.citationNg, L.-C, Tan, L.-K, Tan, C.-H, Tan, S.S.Y, Hapuarachchi, H.C, Pok, K.-Y, Lai, Y.-L, Lam-Phua, S.-G, Bucht, G, Lin, R.T.P, Leo, Y.-S, Tan, B.-H, Han, H.-K, Ooi, P.-L.S, James, L, Khoo, S.-P (2009). Entomologic and virologic investigation of chikungunya, Singapore. Emerging Infectious Diseases 15 (8) : 1243-1249. ScholarBank@NUS Repository. https://doi.org/10.3201/eid1508.081486
dc.identifier.issn10806040
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181010
dc.description.abstractLocal transmission of chikungunya, a debilitating mosquito-borne viral disease, was first reported in Singapore in January 2008. After 3 months of absence, locally acquired Chikungunya cases resurfaced in May 2008, causing an outbreak that resulted in a total of 231 cases by September 2008. The circulating viruses were related to East, Central, and South African genotypes that emerged in the Indian Ocean region in 2005. The first local outbreak was due to a wild-type virus (alanine at codon 226 of the envelope 1 gene) and occurred in an area where Aedes aegypti mosquitoes were the primary vector. Strains isolated during subsequent outbreaks showed alanine to valine substitution (A226V) and largely spread in areas predominated by Ae. albopictus mosquitoes. These findings led to a revision of the current vector control strategy in Singapore. This report highlights the use of entomologic and virologic data to assist in the control of chikungunya in disease-endemic areas.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectalanine
dc.subjectglycoprotein E1
dc.subjectvaline
dc.subjectvirus RNA
dc.subjectAedes aegypti
dc.subjectAedes albopictus
dc.subjectAfrica
dc.subjectamino acid substitution
dc.subjectarticle
dc.subjectChikungunya alphavirus
dc.subjectcontrolled study
dc.subjectdisease surveillance
dc.subjectDNA sequence
dc.subjectepidemic
dc.subjectgene e1
dc.subjectgenotype
dc.subjectgeographic distribution
dc.subjecthuman
dc.subjectinfection control
dc.subjectmajor clinical study
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectphylogeny
dc.subjectSingapore
dc.subjectvector control
dc.subjectvirus gene
dc.subjectvirus infection
dc.subjectwild type
dc.subjectAedes
dc.subjectAlphavirus Infections
dc.subjectAmino Acid Substitution
dc.subjectAnimals
dc.subjectBase Sequence
dc.subjectChikungunya virus
dc.subjectCommunicable Diseases, Emerging
dc.subjectDisease Outbreaks
dc.subjectDNA Primers
dc.subjectDNA, Viral
dc.subjectGenes, env
dc.subjectHumans
dc.subjectInsect Vectors
dc.subjectMolecular Epidemiology
dc.subjectPhylogeny
dc.subjectSingapore
dc.subjectViral Envelope Proteins
dc.typeArticle
dc.contributor.departmentPATHOLOGY
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.3201/eid1508.081486
dc.description.sourcetitleEmerging Infectious Diseases
dc.description.volume15
dc.description.issue8
dc.description.page1243-1249
dc.published.statePublished
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