Please use this identifier to cite or link to this item:
https://doi.org/10.3201/eid1508.081486
DC Field | Value | |
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dc.title | Entomologic and virologic investigation of chikungunya, Singapore | |
dc.contributor.author | Ng, L.-C | |
dc.contributor.author | Tan, L.-K | |
dc.contributor.author | Tan, C.-H | |
dc.contributor.author | Tan, S.S.Y | |
dc.contributor.author | Hapuarachchi, H.C | |
dc.contributor.author | Pok, K.-Y | |
dc.contributor.author | Lai, Y.-L | |
dc.contributor.author | Lam-Phua, S.-G | |
dc.contributor.author | Bucht, G | |
dc.contributor.author | Lin, R.T.P | |
dc.contributor.author | Leo, Y.-S | |
dc.contributor.author | Tan, B.-H | |
dc.contributor.author | Han, H.-K | |
dc.contributor.author | Ooi, P.-L.S | |
dc.contributor.author | James, L | |
dc.contributor.author | Khoo, S.-P | |
dc.date.accessioned | 2020-10-27T06:53:35Z | |
dc.date.available | 2020-10-27T06:53:35Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Ng, L.-C, Tan, L.-K, Tan, C.-H, Tan, S.S.Y, Hapuarachchi, H.C, Pok, K.-Y, Lai, Y.-L, Lam-Phua, S.-G, Bucht, G, Lin, R.T.P, Leo, Y.-S, Tan, B.-H, Han, H.-K, Ooi, P.-L.S, James, L, Khoo, S.-P (2009). Entomologic and virologic investigation of chikungunya, Singapore. Emerging Infectious Diseases 15 (8) : 1243-1249. ScholarBank@NUS Repository. https://doi.org/10.3201/eid1508.081486 | |
dc.identifier.issn | 10806040 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/181010 | |
dc.description.abstract | Local transmission of chikungunya, a debilitating mosquito-borne viral disease, was first reported in Singapore in January 2008. After 3 months of absence, locally acquired Chikungunya cases resurfaced in May 2008, causing an outbreak that resulted in a total of 231 cases by September 2008. The circulating viruses were related to East, Central, and South African genotypes that emerged in the Indian Ocean region in 2005. The first local outbreak was due to a wild-type virus (alanine at codon 226 of the envelope 1 gene) and occurred in an area where Aedes aegypti mosquitoes were the primary vector. Strains isolated during subsequent outbreaks showed alanine to valine substitution (A226V) and largely spread in areas predominated by Ae. albopictus mosquitoes. These findings led to a revision of the current vector control strategy in Singapore. This report highlights the use of entomologic and virologic data to assist in the control of chikungunya in disease-endemic areas. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | alanine | |
dc.subject | glycoprotein E1 | |
dc.subject | valine | |
dc.subject | virus RNA | |
dc.subject | Aedes aegypti | |
dc.subject | Aedes albopictus | |
dc.subject | Africa | |
dc.subject | amino acid substitution | |
dc.subject | article | |
dc.subject | Chikungunya alphavirus | |
dc.subject | controlled study | |
dc.subject | disease surveillance | |
dc.subject | DNA sequence | |
dc.subject | epidemic | |
dc.subject | gene e1 | |
dc.subject | genotype | |
dc.subject | geographic distribution | |
dc.subject | human | |
dc.subject | infection control | |
dc.subject | major clinical study | |
dc.subject | nonhuman | |
dc.subject | nucleotide sequence | |
dc.subject | phylogeny | |
dc.subject | Singapore | |
dc.subject | vector control | |
dc.subject | virus gene | |
dc.subject | virus infection | |
dc.subject | wild type | |
dc.subject | Aedes | |
dc.subject | Alphavirus Infections | |
dc.subject | Amino Acid Substitution | |
dc.subject | Animals | |
dc.subject | Base Sequence | |
dc.subject | Chikungunya virus | |
dc.subject | Communicable Diseases, Emerging | |
dc.subject | Disease Outbreaks | |
dc.subject | DNA Primers | |
dc.subject | DNA, Viral | |
dc.subject | Genes, env | |
dc.subject | Humans | |
dc.subject | Insect Vectors | |
dc.subject | Molecular Epidemiology | |
dc.subject | Phylogeny | |
dc.subject | Singapore | |
dc.subject | Viral Envelope Proteins | |
dc.type | Article | |
dc.contributor.department | PATHOLOGY | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.description.doi | 10.3201/eid1508.081486 | |
dc.description.sourcetitle | Emerging Infectious Diseases | |
dc.description.volume | 15 | |
dc.description.issue | 8 | |
dc.description.page | 1243-1249 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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