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Title: Reassortment of human rotavirus gene segments into G11 rotavirus strains
Authors: Matthijnssens, J
Rahman, M 
Ciarlet, M
Zeller, M
Heylen, E
Nakagomi, T
Uchida, R
Hassan, Z
Azim, T
Nakagomi, O
van Ranst, M
Keywords: nonstructural protein 1
nonstructural protein 2
nonstructural protein 3
nonstructural protein 4
nonstructural protein 5
protein VP1
protein VP2
protein VP3
protein VP4
protein VP6
protein VP7
gene sequence
genetic reassortment
geographic distribution
open reading frame
phylogenetic tree
Rotavirus G11
virus detection
virus genome
virus isolation
virus strain
virus transmission
Genes, Viral
Reassortant Viruses
Reverse Transcriptase Polymerase Chain Reaction
Rotavirus Infections
Sequence Analysis, DNA
Swine Diseases
Issue Date: 2010
Citation: Matthijnssens, J, Rahman, M, Ciarlet, M, Zeller, M, Heylen, E, Nakagomi, T, Uchida, R, Hassan, Z, Azim, T, Nakagomi, O, van Ranst, M (2010). Reassortment of human rotavirus gene segments into G11 rotavirus strains. Emerging Infectious Diseases 16 (4) : 625-630. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: G11 rotaviruses are believed to be of porcine origin. However, a limited number of G11 rotaviruses have been recently isolated from humans in combination with P[25], P[8], P[6], and P[4]. To investigate the evolutionary relationships of these strains, we analyzed the complete genomes of 2 human G11P[25] strains, 2 human G11P[8] strains, and 3 porcine reference strains. Most of the 11 gene segments of these 7 strains belonged to genotype 1 (Wa-like). However, phylogenetic clustering patterns suggested that an unknown G11P[25] strain with a new I12 VP6 genotype was transmitted to the human population, in which it acquired human genotype 1 gene segments through reassortment, resulting in a human G11P[8] rotavirus strain with an entire human Wa-genogroup backbone. This Wa-like backbone is believed to have caused the worldwide spread of human G9 and G12 rotaviruses. G11 human rotavirus strains should be monitored because they may also become major human pathogens.
Source Title: Emerging Infectious Diseases
ISSN: 1080-6040
DOI: 10.3201/eid1604.091591
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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