Please use this identifier to cite or link to this item: https://doi.org/10.3201/eid1604.091591
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dc.titleReassortment of human rotavirus gene segments into G11 rotavirus strains
dc.contributor.authorMatthijnssens, J
dc.contributor.authorRahman, M
dc.contributor.authorCiarlet, M
dc.contributor.authorZeller, M
dc.contributor.authorHeylen, E
dc.contributor.authorNakagomi, T
dc.contributor.authorUchida, R
dc.contributor.authorHassan, Z
dc.contributor.authorAzim, T
dc.contributor.authorNakagomi, O
dc.contributor.authorvan Ranst, M
dc.date.accessioned2020-10-27T06:50:37Z
dc.date.available2020-10-27T06:50:37Z
dc.date.issued2010
dc.identifier.citationMatthijnssens, J, Rahman, M, Ciarlet, M, Zeller, M, Heylen, E, Nakagomi, T, Uchida, R, Hassan, Z, Azim, T, Nakagomi, O, van Ranst, M (2010). Reassortment of human rotavirus gene segments into G11 rotavirus strains. Emerging Infectious Diseases 16 (4) : 625-630. ScholarBank@NUS Repository. https://doi.org/10.3201/eid1604.091591
dc.identifier.issn1080-6040
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/180994
dc.description.abstractG11 rotaviruses are believed to be of porcine origin. However, a limited number of G11 rotaviruses have been recently isolated from humans in combination with P[25], P[8], P[6], and P[4]. To investigate the evolutionary relationships of these strains, we analyzed the complete genomes of 2 human G11P[25] strains, 2 human G11P[8] strains, and 3 porcine reference strains. Most of the 11 gene segments of these 7 strains belonged to genotype 1 (Wa-like). However, phylogenetic clustering patterns suggested that an unknown G11P[25] strain with a new I12 VP6 genotype was transmitted to the human population, in which it acquired human genotype 1 gene segments through reassortment, resulting in a human G11P[8] rotavirus strain with an entire human Wa-genogroup backbone. This Wa-like backbone is believed to have caused the worldwide spread of human G9 and G12 rotaviruses. G11 human rotavirus strains should be monitored because they may also become major human pathogens.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectnonstructural protein 1
dc.subjectnonstructural protein 2
dc.subjectnonstructural protein 3
dc.subjectnonstructural protein 4
dc.subjectnonstructural protein 5
dc.subjectprotein VP1
dc.subjectprotein VP2
dc.subjectprotein VP3
dc.subjectprotein VP4
dc.subjectprotein VP6
dc.subjectprotein VP7
dc.subjectarticle
dc.subjectgene sequence
dc.subjectgenetic reassortment
dc.subjectgenotype
dc.subjectgeographic distribution
dc.subjecthuman
dc.subjectnonhuman
dc.subjectopen reading frame
dc.subjectphylogenetic tree
dc.subjectphylogeny
dc.subjectRotavirus
dc.subjectRotavirus G11
dc.subjectvirus detection
dc.subjectvirus genome
dc.subjectvirus isolation
dc.subjectvirus strain
dc.subjectvirus transmission
dc.subjectAnimals
dc.subjectGenes, Viral
dc.subjectGenotype
dc.subjectHumans
dc.subjectPhylogeny
dc.subjectReassortant Viruses
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectRotavirus
dc.subjectRotavirus Infections
dc.subjectSequence Analysis, DNA
dc.subjectSwine
dc.subjectSwine Diseases
dc.typeArticle
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.3201/eid1604.091591
dc.description.sourcetitleEmerging Infectious Diseases
dc.description.volume16
dc.description.issue4
dc.description.page625-630
dc.published.statePublished
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