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https://doi.org/10.1186/s12916-014-0130-5
| Title: | Cardiovascular risk factors and future risk of Alzheimer's disease | Authors: | de Bruijn, R.F.A.G Ikram, M.A |
Keywords: | homocysteine thyroid hormone Alzheimer disease arterial stiffness Article blood pressure brain atrophy brain hemorrhage cardiovascular disease cardiovascular risk cerebrovascular accident cerebrovascular disease chronic kidney disease cognitive defect dementia diffusion tensor imaging disease association disease marker functional magnetic resonance imaging glucose metabolism heart atrium fibrillation heart disease heart failure human hypercholesterolemia hypertension inflammation ischemic heart disease Mediterranean diet non insulin dependent diabetes mellitus obesity physical activity pulse wave risk assessment smoking thyroid function white matter lesion aged Alzheimer disease amyloid plaque cardiovascular disease complication neurofibrillary tangle pathology risk factor Aged Alzheimer Disease Cardiovascular Diseases Humans Neurofibrillary Tangles Plaque, Amyloid Risk Factors |
Issue Date: | 2014 | Citation: | de Bruijn, R.F.A.G, Ikram, M.A (2014). Cardiovascular risk factors and future risk of Alzheimer's disease. BMC Medicine 12 (1) : 130. ScholarBank@NUS Repository. https://doi.org/10.1186/s12916-014-0130-5 | Rights: | Attribution 4.0 International | Abstract: | Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people, but there are still no curative options. Senile plaques and neurofibrillary tangles are considered hallmarks of AD, but cerebrovascular pathology is also common. In this review, we summarize findings on cardiovascular disease (CVD) and risk factors in the etiology of AD. Firstly, we discuss the association of clinical CVD (such as stroke and heart disease) and AD. Secondly, we summarize the relation between imaging makers of pre-clinical vascular disease and AD. Lastly, we discuss the association of cardiovascular risk factors and AD. We discuss both established cardiovascular risk factors and emerging putative risk factors, which exert their effect partly via CVD. © 2014 de Bruijn and Ikram. | Source Title: | BMC Medicine | URI: | https://scholarbank.nus.edu.sg/handle/10635/180969 | ISSN: | 17417015 | DOI: | 10.1186/s12916-014-0130-5 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Staff Publications Elements |
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