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https://doi.org/10.18632/oncotarget.4301
Title: | Dose coverage of axillary level I-III areas during whole breast irradiation with simplified intensity modulated radiation therapy in early stage breast cancer patients | Authors: | Zhang, L Yang, Z.-Z Chen, X.-X Tuan, J Ma, J.-L Mei, X Yu, X.-L Zhou, Z.-R Shao, Z.-M Liu, G.-Y Guo, X.-M |
Keywords: | adult aged Article breast cancer cancer staging comparative study controlled study dosimetry female field in field intensity modulated radiation therapy human human tissue intensity modulated radiation therapy major clinical study partial mastectomy radiation dose distribution sentinel lymph node biopsy simplified intensity modulated radiation therapy tumor biopsy adjuvant radiotherapy adverse effects Breast Neoplasms lymph node dissection lymph node metastasis mastectomy middle aged pathology procedures radiation dose treatment outcome x-ray computed tomography Adult Aged Breast Neoplasms Female Humans Lymph Node Excision Lymphatic Metastasis Mastectomy Middle Aged Neoplasm Staging Radiation Dosage Radiotherapy, Adjuvant Radiotherapy, Intensity-Modulated Sentinel Lymph Node Biopsy Tomography, X-Ray Computed Treatment Outcome |
Issue Date: | 2015 | Citation: | Zhang, L, Yang, Z.-Z, Chen, X.-X, Tuan, J, Ma, J.-L, Mei, X, Yu, X.-L, Zhou, Z.-R, Shao, Z.-M, Liu, G.-Y, Guo, X.-M (2015). Dose coverage of axillary level I-III areas during whole breast irradiation with simplified intensity modulated radiation therapy in early stage breast cancer patients. Oncotarget 6 (20) : 18183-18191. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.4301 | Rights: | Attribution 4.0 International | Abstract: | Purpose: This study was designed to evaluate the dose coverage of axillary areas during whole breast irradiation with simplified intensity modulated radiation therapy (s-IMRT) and field-in-field IMRT (for-IMRT) in early stage breast cancer patients. Methods: Sixty-one consecutive patients with breast-conserving surgery and sentinel lymph node biopsy were collected. Two plans were created for each patient: the s-IMRT and for-IMRT plan. Dosimetric parameters of axillary areas were compared. Results: The average of mean doses delivered to the axillary level I areas in s-IMRT and for-IMRT plan were 27.7Gy and 29.1Gy (p = 0.011), respectively. The average of V47.5Gy, V45Gy and V40Gy (percent volume receiving? 47.5Gy, 45Gy and 40Gy) of the axillary level I in s-IMRT plan was significantly lower than that in for-IMRT plan (p < 0.001). For for-IMRT plans, patients with upper tangential border to humeral head ?2cm, breast separation >19.3cm and body width >31.9cm had significantly higher mean dose in axillary level I area (p = 0.002, 0.007, 0.001, respectively). Conclusion: Compared with for-IMRT plan, the s-IMRT plan delivered lower dose to axillary level I area. For centers using s-IMRT technique, caution should be exercised when selecting to omit axillary lymph node dissection for patients with breast conserving surgery and limited positive SLNs. | Source Title: | Oncotarget | URI: | https://scholarbank.nus.edu.sg/handle/10635/180945 | ISSN: | 19492553 | DOI: | 10.18632/oncotarget.4301 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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