Please use this identifier to cite or link to this item:
https://doi.org/10.18632/oncotarget.4301
DC Field | Value | |
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dc.title | Dose coverage of axillary level I-III areas during whole breast irradiation with simplified intensity modulated radiation therapy in early stage breast cancer patients | |
dc.contributor.author | Zhang, L | |
dc.contributor.author | Yang, Z.-Z | |
dc.contributor.author | Chen, X.-X | |
dc.contributor.author | Tuan, J | |
dc.contributor.author | Ma, J.-L | |
dc.contributor.author | Mei, X | |
dc.contributor.author | Yu, X.-L | |
dc.contributor.author | Zhou, Z.-R | |
dc.contributor.author | Shao, Z.-M | |
dc.contributor.author | Liu, G.-Y | |
dc.contributor.author | Guo, X.-M | |
dc.date.accessioned | 2020-10-27T05:48:59Z | |
dc.date.available | 2020-10-27T05:48:59Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Zhang, L, Yang, Z.-Z, Chen, X.-X, Tuan, J, Ma, J.-L, Mei, X, Yu, X.-L, Zhou, Z.-R, Shao, Z.-M, Liu, G.-Y, Guo, X.-M (2015). Dose coverage of axillary level I-III areas during whole breast irradiation with simplified intensity modulated radiation therapy in early stage breast cancer patients. Oncotarget 6 (20) : 18183-18191. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.4301 | |
dc.identifier.issn | 19492553 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/180945 | |
dc.description.abstract | Purpose: This study was designed to evaluate the dose coverage of axillary areas during whole breast irradiation with simplified intensity modulated radiation therapy (s-IMRT) and field-in-field IMRT (for-IMRT) in early stage breast cancer patients. Methods: Sixty-one consecutive patients with breast-conserving surgery and sentinel lymph node biopsy were collected. Two plans were created for each patient: the s-IMRT and for-IMRT plan. Dosimetric parameters of axillary areas were compared. Results: The average of mean doses delivered to the axillary level I areas in s-IMRT and for-IMRT plan were 27.7Gy and 29.1Gy (p = 0.011), respectively. The average of V47.5Gy, V45Gy and V40Gy (percent volume receiving? 47.5Gy, 45Gy and 40Gy) of the axillary level I in s-IMRT plan was significantly lower than that in for-IMRT plan (p < 0.001). For for-IMRT plans, patients with upper tangential border to humeral head ?2cm, breast separation >19.3cm and body width >31.9cm had significantly higher mean dose in axillary level I area (p = 0.002, 0.007, 0.001, respectively). Conclusion: Compared with for-IMRT plan, the s-IMRT plan delivered lower dose to axillary level I area. For centers using s-IMRT technique, caution should be exercised when selecting to omit axillary lymph node dissection for patients with breast conserving surgery and limited positive SLNs. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | adult | |
dc.subject | aged | |
dc.subject | Article | |
dc.subject | breast cancer | |
dc.subject | cancer staging | |
dc.subject | comparative study | |
dc.subject | controlled study | |
dc.subject | dosimetry | |
dc.subject | female | |
dc.subject | field in field intensity modulated radiation therapy | |
dc.subject | human | |
dc.subject | human tissue | |
dc.subject | intensity modulated radiation therapy | |
dc.subject | major clinical study | |
dc.subject | partial mastectomy | |
dc.subject | radiation dose distribution | |
dc.subject | sentinel lymph node biopsy | |
dc.subject | simplified intensity modulated radiation therapy | |
dc.subject | tumor biopsy | |
dc.subject | adjuvant radiotherapy | |
dc.subject | adverse effects | |
dc.subject | Breast Neoplasms | |
dc.subject | lymph node dissection | |
dc.subject | lymph node metastasis | |
dc.subject | mastectomy | |
dc.subject | middle aged | |
dc.subject | pathology | |
dc.subject | procedures | |
dc.subject | radiation dose | |
dc.subject | treatment outcome | |
dc.subject | x-ray computed tomography | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Breast Neoplasms | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Lymph Node Excision | |
dc.subject | Lymphatic Metastasis | |
dc.subject | Mastectomy | |
dc.subject | Middle Aged | |
dc.subject | Neoplasm Staging | |
dc.subject | Radiation Dosage | |
dc.subject | Radiotherapy, Adjuvant | |
dc.subject | Radiotherapy, Intensity-Modulated | |
dc.subject | Sentinel Lymph Node Biopsy | |
dc.subject | Tomography, X-Ray Computed | |
dc.subject | Treatment Outcome | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.18632/oncotarget.4301 | |
dc.description.sourcetitle | Oncotarget | |
dc.description.volume | 6 | |
dc.description.issue | 20 | |
dc.description.page | 18183-18191 | |
Appears in Collections: | Staff Publications Elements |
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