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https://doi.org/10.3390/molecules18010934
Title: | Total flavonoids of scutellaria barbata inhibit invasion of hepatocarcinoma via MMP/TIMP in Vitro | Authors: | Dai, Z.-J Wang, B.-F Lu, W.-F Wang, Z.-D Ma, X.-B Min, W.-L Kang, H.-F Wang, X.-J Wu, W.-Y |
Keywords: | antineoplastic agent flavonoid gelatinase A gelatinase B MMP2 protein, human MMP9 protein, human plant extract TIMP1 protein, human TIMP2 protein, human tissue inhibitor of metalloproteinase 1 tissue inhibitor of metalloproteinase 2 article cell motion cell proliferation chemistry drug effect gene expression gene expression regulation genetics human IC 50 liver cell carcinoma metabolism Scutellaria tumor cell line Antineoplastic Agents, Phytogenic Carcinoma, Hepatocellular Cell Line, Tumor Cell Movement Cell Proliferation Flavonoids Gene Expression Gene Expression Regulation Humans Inhibitory Concentration 50 Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Plant Extracts Scutellaria Tissue Inhibitor of Metalloproteinase-1 Tissue Inhibitor of Metalloproteinase-2 |
Issue Date: | 2013 | Citation: | Dai, Z.-J, Wang, B.-F, Lu, W.-F, Wang, Z.-D, Ma, X.-B, Min, W.-L, Kang, H.-F, Wang, X.-J, Wu, W.-Y (2013). Total flavonoids of scutellaria barbata inhibit invasion of hepatocarcinoma via MMP/TIMP in Vitro. Molecules 18 (1) : 934-950. ScholarBank@NUS Repository. https://doi.org/10.3390/molecules18010934 | Rights: | Attribution 4.0 International | Abstract: | Metastasis is the major cause of cancer-related deaths. Targeting the process of metastasis has been proposed as a strategy to fight cancer. Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, is used for treatment of many diseases, including cancer. This study aimed to determine the anti-metastatic effect of total flavonoids of S. barbata (TF-SB) using the human hepatocarcinoma MHCC97H cell line with high metastatic potential. Our results show that TF-SB could significantly inhibit the proliferation and invasion of MHCC97H cells in a dose-dependent manner. MMP-2 and MMP-9 expression were obviously decreased after TF-SB treatment at both the mRNA and protein level. TIMP-1 and TIMP-2 expression were simultaneously increased. The present study indicates that TF-SB could reduce the metastatic capability of MHCC97H cell, probably through decrease of the MMP expression, and simultaneous increase of the TIMP expression. © 2013 by the authors. | Source Title: | Molecules | URI: | https://scholarbank.nus.edu.sg/handle/10635/180811 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules18010934 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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