Please use this identifier to cite or link to this item:
https://doi.org/10.3390/molecules18010934
DC Field | Value | |
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dc.title | Total flavonoids of scutellaria barbata inhibit invasion of hepatocarcinoma via MMP/TIMP in Vitro | |
dc.contributor.author | Dai, Z.-J | |
dc.contributor.author | Wang, B.-F | |
dc.contributor.author | Lu, W.-F | |
dc.contributor.author | Wang, Z.-D | |
dc.contributor.author | Ma, X.-B | |
dc.contributor.author | Min, W.-L | |
dc.contributor.author | Kang, H.-F | |
dc.contributor.author | Wang, X.-J | |
dc.contributor.author | Wu, W.-Y | |
dc.date.accessioned | 2020-10-27T04:49:43Z | |
dc.date.available | 2020-10-27T04:49:43Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Dai, Z.-J, Wang, B.-F, Lu, W.-F, Wang, Z.-D, Ma, X.-B, Min, W.-L, Kang, H.-F, Wang, X.-J, Wu, W.-Y (2013). Total flavonoids of scutellaria barbata inhibit invasion of hepatocarcinoma via MMP/TIMP in Vitro. Molecules 18 (1) : 934-950. ScholarBank@NUS Repository. https://doi.org/10.3390/molecules18010934 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/180811 | |
dc.description.abstract | Metastasis is the major cause of cancer-related deaths. Targeting the process of metastasis has been proposed as a strategy to fight cancer. Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, is used for treatment of many diseases, including cancer. This study aimed to determine the anti-metastatic effect of total flavonoids of S. barbata (TF-SB) using the human hepatocarcinoma MHCC97H cell line with high metastatic potential. Our results show that TF-SB could significantly inhibit the proliferation and invasion of MHCC97H cells in a dose-dependent manner. MMP-2 and MMP-9 expression were obviously decreased after TF-SB treatment at both the mRNA and protein level. TIMP-1 and TIMP-2 expression were simultaneously increased. The present study indicates that TF-SB could reduce the metastatic capability of MHCC97H cell, probably through decrease of the MMP expression, and simultaneous increase of the TIMP expression. © 2013 by the authors. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | antineoplastic agent | |
dc.subject | flavonoid | |
dc.subject | gelatinase A | |
dc.subject | gelatinase B | |
dc.subject | MMP2 protein, human | |
dc.subject | MMP9 protein, human | |
dc.subject | plant extract | |
dc.subject | TIMP1 protein, human | |
dc.subject | TIMP2 protein, human | |
dc.subject | tissue inhibitor of metalloproteinase 1 | |
dc.subject | tissue inhibitor of metalloproteinase 2 | |
dc.subject | article | |
dc.subject | cell motion | |
dc.subject | cell proliferation | |
dc.subject | chemistry | |
dc.subject | drug effect | |
dc.subject | gene expression | |
dc.subject | gene expression regulation | |
dc.subject | genetics | |
dc.subject | human | |
dc.subject | IC 50 | |
dc.subject | liver cell carcinoma | |
dc.subject | metabolism | |
dc.subject | Scutellaria | |
dc.subject | tumor cell line | |
dc.subject | Antineoplastic Agents, Phytogenic | |
dc.subject | Carcinoma, Hepatocellular | |
dc.subject | Cell Line, Tumor | |
dc.subject | Cell Movement | |
dc.subject | Cell Proliferation | |
dc.subject | Flavonoids | |
dc.subject | Gene Expression | |
dc.subject | Gene Expression Regulation | |
dc.subject | Humans | |
dc.subject | Inhibitory Concentration 50 | |
dc.subject | Matrix Metalloproteinase 2 | |
dc.subject | Matrix Metalloproteinase 9 | |
dc.subject | Plant Extracts | |
dc.subject | Scutellaria | |
dc.subject | Tissue Inhibitor of Metalloproteinase-1 | |
dc.subject | Tissue Inhibitor of Metalloproteinase-2 | |
dc.type | Article | |
dc.contributor.department | MECHANICAL ENGINEERING | |
dc.description.doi | 10.3390/molecules18010934 | |
dc.description.sourcetitle | Molecules | |
dc.description.volume | 18 | |
dc.description.issue | 1 | |
dc.description.page | 934-950 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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