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https://doi.org/10.1038/ncomms9888
| Title: | Novel RNA-and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity | Authors: | Zhang, P Abdelmohsen, K Liu, Y Tominaga-Yamanaka, K Yoon, J.-H Ioannis, G Martindale, J.L Zhang, Y Becker, K.G Yang, I.H Gorospe, M Mattson, M.P |
Keywords: | alpha tubulin fragile X mental retardation protein messenger RNA telomeric repeat binding factor 2 TRF2 S protein unclassified drug carrier protein Fmr1 protein, mouse fragile X mental retardation protein messenger RNA RNA binding protein telomeric repeat binding factor 2 TRF2 protein, mouse genetic analysis neurology plasticity protein RNA adult animal experiment animal tissue Article binding site brain cell cell differentiation cell growth controlled study dendrite Enterobacteria phage MS2 female hippocampal neuronal culture human human cell mitochondrial membrane mouse multigene family nerve cell plasticity nerve fiber neurotransmitter release nonhuman nuclear export signal presynaptic nerve protein assembly protein cross linking protein domain protein expression protein motif protein RNA binding rat reverse transcription RNA transport synaptic transmission synaptogenesis synaptosome animal axon C57BL mouse genetics knockout mouse male metabolism nerve fiber transport Sprague Dawley rat transport at the cellular level Animals Axonal Transport Axons Biological Transport Carrier Proteins Female Fragile X Mental Retardation Protein Humans Male Mice Mice, Inbred C57BL Mice, Knockout Rats Rats, Sprague-Dawley RNA, Messenger RNA-Binding Proteins Telomeric Repeat Binding Protein 2 |
Issue Date: | 2015 | Publisher: | Nature Publishing Group | Citation: | Zhang, P, Abdelmohsen, K, Liu, Y, Tominaga-Yamanaka, K, Yoon, J.-H, Ioannis, G, Martindale, J.L, Zhang, Y, Becker, K.G, Yang, I.H, Gorospe, M, Mattson, M.P (2015). Novel RNA-and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity. Nature Communications 6 : 8888. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms9888 | Rights: | Attribution 4.0 International | Abstract: | Despite considerable evidence that RNA-binding proteins (RBPs) regulate mRNA transport and local translation in dendrites, roles for axonal RBPs are poorly understood. Here we demonstrate that a non-telomeric isoform of telomere repeat-binding factor 2 (TRF2-S) is a novel RBP that regulates axonal plasticity. TRF2-S interacts directly with target mRNAs to facilitate their axonal delivery. The process is antagonized by fragile X mental retardation protein (FMRP). Distinct from the current RNA-binding model of FMRP, we show that FMRP occupies the GAR domain of TRF2-S protein to block the assembly of TRF2-S-mRNA complexes. Overexpressing TRF2-S and silencing FMRP promotes mRNA entry to axons and enhances axonal outgrowth and neurotransmitter release from presynaptic terminals. Our findings suggest a pivotal role for TRF2-S in an axonal mRNA localization pathway that enhances axon outgrowth and neurotransmitter release. © 2015 Macmillan Publishers Limited. All rights reserved. | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/180414 | ISSN: | 2041-1723 | DOI: | 10.1038/ncomms9888 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Elements Staff Publications |
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