Please use this identifier to cite or link to this item:
https://doi.org/10.1038/ncomms9888
DC Field | Value | |
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dc.title | Novel RNA-and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity | |
dc.contributor.author | Zhang, P | |
dc.contributor.author | Abdelmohsen, K | |
dc.contributor.author | Liu, Y | |
dc.contributor.author | Tominaga-Yamanaka, K | |
dc.contributor.author | Yoon, J.-H | |
dc.contributor.author | Ioannis, G | |
dc.contributor.author | Martindale, J.L | |
dc.contributor.author | Zhang, Y | |
dc.contributor.author | Becker, K.G | |
dc.contributor.author | Yang, I.H | |
dc.contributor.author | Gorospe, M | |
dc.contributor.author | Mattson, M.P | |
dc.date.accessioned | 2020-10-26T08:52:56Z | |
dc.date.available | 2020-10-26T08:52:56Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Zhang, P, Abdelmohsen, K, Liu, Y, Tominaga-Yamanaka, K, Yoon, J.-H, Ioannis, G, Martindale, J.L, Zhang, Y, Becker, K.G, Yang, I.H, Gorospe, M, Mattson, M.P (2015). Novel RNA-and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity. Nature Communications 6 : 8888. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms9888 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/180414 | |
dc.description.abstract | Despite considerable evidence that RNA-binding proteins (RBPs) regulate mRNA transport and local translation in dendrites, roles for axonal RBPs are poorly understood. Here we demonstrate that a non-telomeric isoform of telomere repeat-binding factor 2 (TRF2-S) is a novel RBP that regulates axonal plasticity. TRF2-S interacts directly with target mRNAs to facilitate their axonal delivery. The process is antagonized by fragile X mental retardation protein (FMRP). Distinct from the current RNA-binding model of FMRP, we show that FMRP occupies the GAR domain of TRF2-S protein to block the assembly of TRF2-S-mRNA complexes. Overexpressing TRF2-S and silencing FMRP promotes mRNA entry to axons and enhances axonal outgrowth and neurotransmitter release from presynaptic terminals. Our findings suggest a pivotal role for TRF2-S in an axonal mRNA localization pathway that enhances axon outgrowth and neurotransmitter release. © 2015 Macmillan Publishers Limited. All rights reserved. | |
dc.publisher | Nature Publishing Group | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | alpha tubulin | |
dc.subject | fragile X mental retardation protein | |
dc.subject | messenger RNA | |
dc.subject | telomeric repeat binding factor 2 | |
dc.subject | TRF2 S protein | |
dc.subject | unclassified drug | |
dc.subject | carrier protein | |
dc.subject | Fmr1 protein, mouse | |
dc.subject | fragile X mental retardation protein | |
dc.subject | messenger RNA | |
dc.subject | RNA binding protein | |
dc.subject | telomeric repeat binding factor 2 | |
dc.subject | TRF2 protein, mouse | |
dc.subject | genetic analysis | |
dc.subject | neurology | |
dc.subject | plasticity | |
dc.subject | protein | |
dc.subject | RNA | |
dc.subject | adult | |
dc.subject | animal experiment | |
dc.subject | animal tissue | |
dc.subject | Article | |
dc.subject | binding site | |
dc.subject | brain cell | |
dc.subject | cell differentiation | |
dc.subject | cell growth | |
dc.subject | controlled study | |
dc.subject | dendrite | |
dc.subject | Enterobacteria phage MS2 | |
dc.subject | female | |
dc.subject | hippocampal neuronal culture | |
dc.subject | human | |
dc.subject | human cell | |
dc.subject | mitochondrial membrane | |
dc.subject | mouse | |
dc.subject | multigene family | |
dc.subject | nerve cell plasticity | |
dc.subject | nerve fiber | |
dc.subject | neurotransmitter release | |
dc.subject | nonhuman | |
dc.subject | nuclear export signal | |
dc.subject | presynaptic nerve | |
dc.subject | protein assembly | |
dc.subject | protein cross linking | |
dc.subject | protein domain | |
dc.subject | protein expression | |
dc.subject | protein motif | |
dc.subject | protein RNA binding | |
dc.subject | rat | |
dc.subject | reverse transcription | |
dc.subject | RNA transport | |
dc.subject | synaptic transmission | |
dc.subject | synaptogenesis | |
dc.subject | synaptosome | |
dc.subject | animal | |
dc.subject | axon | |
dc.subject | C57BL mouse | |
dc.subject | genetics | |
dc.subject | knockout mouse | |
dc.subject | male | |
dc.subject | metabolism | |
dc.subject | nerve fiber transport | |
dc.subject | Sprague Dawley rat | |
dc.subject | transport at the cellular level | |
dc.subject | Animals | |
dc.subject | Axonal Transport | |
dc.subject | Axons | |
dc.subject | Biological Transport | |
dc.subject | Carrier Proteins | |
dc.subject | Female | |
dc.subject | Fragile X Mental Retardation Protein | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Mice | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mice, Knockout | |
dc.subject | Rats | |
dc.subject | Rats, Sprague-Dawley | |
dc.subject | RNA, Messenger | |
dc.subject | RNA-Binding Proteins | |
dc.subject | Telomeric Repeat Binding Protein 2 | |
dc.type | Article | |
dc.contributor.department | LIFE SCIENCES INSTITUTE | |
dc.description.doi | 10.1038/ncomms9888 | |
dc.description.sourcetitle | Nature Communications | |
dc.description.volume | 6 | |
dc.description.page | 8888 | |
dc.published.state | published | |
Appears in Collections: | Elements Staff Publications |
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