Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.10091
Title: White matter degeneration in subjective cognitive decline: A diffusion tensor imaging study
Authors: Li, X.-Y
Tang, Z.-C
Sun, Y 
Tian, J
Liu, Z.-Y
Han, Y
Keywords: adult
aged
aging
Alzheimer disease
Article
axial diffusivity
brain degeneration
cognitive defect
controlled study
diffusion tensor imaging
female
fractional anisotropy
human
image analysis
major clinical study
male
mean diffusivity
memory disorder
mild cognitive impairment
neuropsychological test
nuclear magnetic resonance scanner
physical parameters
radial diffusivity
recall
white matter
anisotropy
cognitive defect
diagnostic imaging
diffusion tensor imaging
middle aged
pathology
procedures
psychology
white matter
Aged
Anisotropy
Cognitive Dysfunction
Diffusion Tensor Imaging
Female
Humans
Male
Middle Aged
Neuropsychological Tests
White Matter
Issue Date: 2016
Publisher: Impact Journals LLC
Citation: Li, X.-Y, Tang, Z.-C, Sun, Y, Tian, J, Liu, Z.-Y, Han, Y (2016). White matter degeneration in subjective cognitive decline: A diffusion tensor imaging study. Oncotarget 7 (34) : 54405-54414. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.10091
Rights: Attribution 4.0 International
Abstract: Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer's disease (AD) occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) defects in SCD, diffusion images from 27 SCD (age=65.3±8.0), 35 aMCI (age=69.2±8.6) and 25 AD patients (age=68.3±9.4) and 37 normal controls (NC) (age=65.1±6.8) were compared using Tract-Based Spatial Statistics (TBSS). WM impairments common to the three patient groups were extracted, and fractional anisotropy (FA) values were averaged in each group. As compared to NC subjects, SCD patients displayed widespread WM alterations represented by decreased FA (p < 0.05), increased mean diffusivity (MD; p < 0.05), and increased radial diffusivity (RD; p < 0.05). In addition, localized WM alterations showed increased axial diffusivity (AxD; p < 0.05) similar to what was observed in aMCI and AD patients (p < 0.05). In the shared WM impairment tracts, SCD patients had FA values between the NC group and the other two patient groups. In the NC and SCD groups, the AVLT-delayed recall score correlated with higher AxD (r=-0.333, p=0.045), MD (r=-0.351, p=0.03) and RD (r=-0.353, p=0.025). In both the aMCI and AD groups the diffusion parameters were highly correlated with cognitive scores. Our study suggests that SCD patients present with widespread WM changes, which may contribute to the early memory decline they experience.
Source Title: Oncotarget
URI: https://scholarbank.nus.edu.sg/handle/10635/180386
ISSN: 1949-2553
DOI: 10.18632/oncotarget.10091
Rights: Attribution 4.0 International
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