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https://doi.org/10.18632/oncotarget.10091
Title: | White matter degeneration in subjective cognitive decline: A diffusion tensor imaging study | Authors: | Li, X.-Y Tang, Z.-C Sun, Y Tian, J Liu, Z.-Y Han, Y |
Keywords: | adult aged aging Alzheimer disease Article axial diffusivity brain degeneration cognitive defect controlled study diffusion tensor imaging female fractional anisotropy human image analysis major clinical study male mean diffusivity memory disorder mild cognitive impairment neuropsychological test nuclear magnetic resonance scanner physical parameters radial diffusivity recall white matter anisotropy cognitive defect diagnostic imaging diffusion tensor imaging middle aged pathology procedures psychology white matter Aged Anisotropy Cognitive Dysfunction Diffusion Tensor Imaging Female Humans Male Middle Aged Neuropsychological Tests White Matter |
Issue Date: | 2016 | Publisher: | Impact Journals LLC | Citation: | Li, X.-Y, Tang, Z.-C, Sun, Y, Tian, J, Liu, Z.-Y, Han, Y (2016). White matter degeneration in subjective cognitive decline: A diffusion tensor imaging study. Oncotarget 7 (34) : 54405-54414. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.10091 | Rights: | Attribution 4.0 International | Abstract: | Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer's disease (AD) occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) defects in SCD, diffusion images from 27 SCD (age=65.3±8.0), 35 aMCI (age=69.2±8.6) and 25 AD patients (age=68.3±9.4) and 37 normal controls (NC) (age=65.1±6.8) were compared using Tract-Based Spatial Statistics (TBSS). WM impairments common to the three patient groups were extracted, and fractional anisotropy (FA) values were averaged in each group. As compared to NC subjects, SCD patients displayed widespread WM alterations represented by decreased FA (p < 0.05), increased mean diffusivity (MD; p < 0.05), and increased radial diffusivity (RD; p < 0.05). In addition, localized WM alterations showed increased axial diffusivity (AxD; p < 0.05) similar to what was observed in aMCI and AD patients (p < 0.05). In the shared WM impairment tracts, SCD patients had FA values between the NC group and the other two patient groups. In the NC and SCD groups, the AVLT-delayed recall score correlated with higher AxD (r=-0.333, p=0.045), MD (r=-0.351, p=0.03) and RD (r=-0.353, p=0.025). In both the aMCI and AD groups the diffusion parameters were highly correlated with cognitive scores. Our study suggests that SCD patients present with widespread WM changes, which may contribute to the early memory decline they experience. | Source Title: | Oncotarget | URI: | https://scholarbank.nus.edu.sg/handle/10635/180386 | ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.10091 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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